KEGG: Kyoto Encyclopedia of Genes and Genomes
KEGG: Kyoto Encyclopedia of Genes and Genomes
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DOI：
10.1093/nar/28.1.27
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发表时间：
2000-01-01
影响因子：
14.9
通讯作者：
Goto, S
中科院分区：
文献类型：
--
作者：
Kanehisa, M;Goto, S
KEGG（京都基因与基因组百科全书）是一个用于基因功能系统分析的知识库，它将基因组信息与更高级的功能信息相联系。基因组信息存储在GENES数据库中，该数据库是所有已完全测序的基因组以及一些部分基因组的基因目录集合，包含最新的基因功能注释。更高级的功能信息存储在PATHWAY数据库中，该数据库包含细胞过程的图形表示，例如代谢、膜转运、信号转导和细胞周期。PATHWAY数据库由一组直系同源组表补充，这些表包含有关保守子通路（通路基序）的信息，这些子通路通常由染色体上位置相连的基因编码，在预测基因功能方面特别有用。KEGG中的第三个数据库是LIGAND，用于存储有关化合物、酶分子和酶促反应的信息。KEGG提供Java图形工具用于浏览基因组图谱、比较两个基因组图谱以及操作表达图谱，还提供用于序列比较、图形比较和路径计算的计算工具。KEGG数据库每日更新，并可免费获取（http://www.genome.ad.jp/kegg/）
KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information, The genomic information is stored in the GENES database, which is a collection of gene catalogs for all the completely sequenced genomes and some partial genomes with up-to-date annotation of gene functions, The higher order functional information is stored in the PATHWAY database, which contains graphical representations of cellular processes, such as metabolism, membrane transport, signal transduction and cell cycle. The PATHWAY database is supplemented by a set of ortholog group tables for the information about conserved subpathways (pathway motifs), which are often encoded by positionally coupled genes on the chromosome and which are especially useful in predicting gene functions. A third database in KEGG is LIGAND for the information about chemical compounds, enzyme molecules and enzymatic reactions. KEGG provides Java graphics tools for browsing genome maps, comparing two genome maps and manipulating expression maps, as well as computational tools for sequence comparison, graph comparison and path computation. The KEGG databases are daily updated and made freely available (http://www.genome.ad.jp/kegg/).