Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977).
Correlation of clinical findings with quinacrine-banded chromosomes in 90 adults with acute nonlymphocytic leukemia: an eight-year study (1970-1977).
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90 名成人急性非淋巴细胞白血病临床结果与奎纳克林带状染色体的相关性：一项为期八年的研究（1970-1977）。
DOI：
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发表时间：
1978
影响因子：
158.5
通讯作者：
Uri Mintz
中科院分区：
文献类型：
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作者：
H. M. Golomb;J. Vardiman;Janet D. Rowley;Joseph R. Testa;Uri Mintz
我们观察到46（51%）的90例成人急性非淋巴细胞白血病在最初入院时的白血病细胞染色体显带异常。37名最初核型正常的患者（10个月）和43名最初核型异常的患者（4个月）之间的生存差异是显著的（P <0.01）。当患者被分为急性髓细胞性白血病或急性粒单核细胞性白血病时，这种生存差异甚至更加明显。在16例核型正常的急性髓性白血病患者中，11例（69%）完全缓解，中位生存期为13个月。在8例仅观察到异常中期细胞的急性髓性白血病患者中，无一完全缓解，中位生存期仅为2个月（P约0.50）。根据初始核型分组的急性粒单核细胞白血病患者的缓解率和中位生存期无显著差异。
We observed chromosome-banding abnormalities in leukemic cells of 46 of 90 (51 per cent) adults with acute nonlymphocytic leukemia at initial hospital admission. The difference in survival between 37 treated patients with an initially normal karyotype (10 months) and 43 with an initially abnormal karyotype (four months) was significant (P less than 0.01). When patients were classified as having acute myelogenous leukemia or acute myelomonocytic leukemia, this difference in survival was even more pronounced. Of 16 treated patients with acute myelogenous leukemia and a normal karyotype, 11 (69 per cent) had a complete remission and a median survival of 13 months. Of eight patients with acute myelogenous leukemia in whom only abnormal metaphases were observed, none had a complete remission, and the median survival was only two months (P approximately 0.50). Remission rate and median survival were not significantly different in patients with acute myelomonocytic leukemia grouped according to initial karyotypes.