Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy
Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy
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DOI：
10.1016/j.jep.2010.10.012
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发表时间：
2011-01-27
影响因子：
5.4
通讯作者：
Lin, Shanyan
中科院分区：
文献类型：
--
作者：
Li, Mingxin;Wang, Weixin;Lin, Shanyan
研究目的：目前糖尿病肾病已成为一个严重的问题。黄芪是中国和东亚用于治疗肾脏疾病数千年的传统草药。在现代医学中，黄芪对DN有明显的肾保护作用。我们的目的是系统地回顾随机和半随机对照试验，以确定其在治疗DN中的作用。资料和方法：采用计算机检索和人工检索的方法检索PUBMED、MEDLINE、中国期刊全文数据库（CJFD）、中国生物医学数据库。每项试验由两名评估员独立审查。共纳入25项研究，包括21项rct和4项Cas，共纳入1804例患者（治疗组945例，对照组859例）。结果与结论：黄芪注射液对DN患者的治疗效果优于对照组，包括肾保护作用（BUN、SCr、CCr、尿蛋白）和全身状态改善（血清白蛋白水平）。民族药理学相关性：本研究探讨黄芪对DN患者的影响。提示虽然黄芪的生物活性成分和肾保护机制尚不清楚，但其治疗DN的作用是可以揭示的，具有深远的意义。2010爱思唯尔爱尔兰有限公司版权所有。
Aim of study: Nowadays diabetic nephropathy (ON) has become a serious problem. Astragalus membranaceus is a traditional herb used for thousands of years in China and East Asia for kidney disease. In modern medicine, Astragalus shows significant renal protective effect in DN. We aimed to systematically review the randomized and semi-randomized control trials to ascertain its role in the treatment of DN.Materials and methods: PUBMED, MEDLINE, Chinese journal full-test database (CJFD), Chinese biological and medical database were searched by computer and manual searching. Two assessors independently reviewed each trial. 25 studies comprising 21 RCTs and 4 Cas were involved including 1804 patients (945 in treatment group and 859 in control group).Results and conclusions: Astragalus injection had more therapeutic effect in DN patients including renal protective effect (BUN, SCr, CCr and urine protein) and systemic state improvement (serum albumin level) compared with the control group.Ethnopharmacological relevance: This study investigates the effect of Astragalus in DN patients. It suggests that although of unknown bioactive ingredients and mechanism of renal protection, the role of Astragalus in the treatment of DN can be disclosed and of profound significance. (C) 2010 Elsevier Ireland Ltd. All rights reserved.