euHCVdb: the European hepatitis C virus database.
euHCVdb: the European hepatitis C virus database.
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EUHCVDB：欧洲丙型肝炎病毒数据库。
DOI：
10.1093/nar/gkl970
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Deleage, Gilbert
中科院分区：
文献类型：
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作者：
Combet, Christophe;Garnier, Nicolas;Charavay, Celine;Grando, Delphine;Crisan, Daniel;Lopez, Julien;Dehne-Garcia, Alexandre;Geourjon, Christophe;Bettler, Emmanuel;Hulo, Chantal;Le Mercier, Philippe;Bartenschlager, Ralf;Diepolder, Helmut;Moradpour, Darius;Pawlotsky, Jean-Michel;Rice, Charles M;Trepo, Christian;Penin, Francois;Deleage, Gilbert
丙型肝炎病毒（HCV）基因组显示出显著的序列变异性，导致在给定宿主内至少分类为六种主要基因型，许多亚型和无数准种。一个允许研究人员调查所有可用HCV序列的遗传和结构变异性的数据库是研究丙型肝炎分子病毒学和发病机制以及药物设计和疫苗开发的重要工具。我们在此描述欧洲丙型肝炎病毒数据库（euHCVdb），这是一个基于参考基因组的计算机注释序列的集合。注释包括序列的基因组定位，推荐命名法的使用，亚型以及蛋白质的三维（3D）分子模型。开发了一个WWW接口，以方便数据库搜索和数据导出，以便进行序列和结构分析。作为与美国和日本数据库国际合作的一部分，欧洲HCV数据库（euHCVdb）主要致力于HCV蛋白序列、3D结构和功能分析。
The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, ), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.