Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila
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DOI：
10.1126/science.277.5327.834
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发表时间：
1997-08-08
期刊：
影响因子：
56.9
通讯作者：
Sokolowski, MB
中科院分区：
文献类型：
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作者：
Osborne, KA;Robichon, A;Sokolowski, MB
自然发生的行为多态性很难进行遗传作图，因此难以进行分子表征。一个例外是觅食基因（for），这个基因在果蝇的食物搜索行为中有两个自然发生的变体：漫游者和栖息者。dg2基因突变的分子图谱，该基因编码环磷酸鸟苷（cGMP）依赖性蛋白激酶（PKG）。转基因小鼠的PKG活性明显高于转基因小鼠，转基因小鼠的行为表现出向转基因小鼠的转变。因此，PKG水平影响食物搜索行为，PKG活性的自然变化解释了行为多态性。
Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Revers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.