Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder
Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder
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DOI：
10.1001/archpsyc.60.12.1201
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发表时间：
2003-12-01
影响因子：
--
通讯作者：
Peterson, BS
中科院分区：
文献类型：
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作者：
Blumberg, HP;Kaufman, J;Peterson, BS
背景：内侧颞叶结构的功能表明它们参与双相情感障碍（BD）的病理生理。先前关于双相障碍患者杏仁核和海马体体积异常的报道结果不一致，而且仅限于成人样本。体积异常是否为双相障碍的早期特征，或者异常是否代表与疾病持续时间相关的神经退行性改变，由于缺乏青少年样本数据而受到限制。目的：研究成人和青少年BD患者的杏仁核和海马体积。环境和参与者：在大学医院或退伍军人医疗中心或周边社区门诊治疗BD I型的36例（青少年14例，成人22例）和56例健康对照（青少年23例，成人33例）。设计和主要结果测量：通过高分辨率解剖磁共振成像扫描确定和测量杏仁核和海马体积。我们使用混合模型、重复测量的统计分析来比较各组的杏仁核和海马体积，同时共变总脑容量、年龄和性别。研究了疾病特征的潜在影响，包括快速循环、药物、酒精或其他物质依赖、持续时间和情绪状态。结果：对于杏仁核和海马区，我们发现与对照组相比，BD的总体体积显著减少(P
Background: The purported functions of medial temporal lobe structures suggest their involvement in the pathophysiology of bipolar disorder (BD). Previous reports of abnormalities in the volume of the amygdala and hippocampus in patients with BD have been inconsistent in their findings and limited to adult samples. Appreciation of whether volumetric abnormalities are early features of BD or whether the abnormalities represent neurodegenerative changes associated with illness duration is limited by the paucity of data in juvenile samples.Objective: To investigate amygdala and hippocampal volume in adults and adolescents with BD.Setting and Participants: Subjects included 36 individuals (14 adolescents and 22 adults) in outpatient treatment for BD type I at a university hospital or Veterans Affairs medical center or in the surrounding community, and 56 healthy comparison subjects (23 adolescents and 33 adults).Design and Main Outcome Measures: Amygdala and hippocampal volumes were defined and measured on high-resolution anatomic magnetic resonance imaging scans. We used a mixed-model, repeated-measures statistical analysis to compare amygdala and hippocampal volumes across groups while covarying for total brain volume, age, and sex. Potential effects of illness features were explored, including rapid cycling, medication, alcohol or other substance dependence, duration, and mood state.Results: For both the amygdala and hippocampal regions, we found an overall significant volume reduction in the BD compared with the control group (P