Structure and properties of ovalbumin
Structure and properties of ovalbumin
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DOI：
10.1016/s0378-4347(01)00108-6
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发表时间：
2001-05-25
期刊：
影响因子：
--
通讯作者：
Stein, PE
中科院分区：
文献类型：
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作者：
Huntington, JA;Stein, PE
卵清蛋白是一种功能未知的蛋白质，大量存在于禽类卵清中。令人惊讶的是，卵清蛋白属于丝氨酸蛋白酶抑制剂家族，尽管它缺乏任何蛋白酶抑制活性。本文综述了卵清蛋白的氨基酸序列、翻译后修饰和三级结构。卵清蛋白的性质进行了讨论，其可能的功能意义。这些包括卵清蛋白未能经历涉及反应中心环的典型Serpin构象变化的原因，这解释了为什么卵清蛋白不是蛋白酶抑制剂，以及卵清蛋白自然转化为更稳定的“S”形式。(C)2001 Elsevier Science B.V.保留所有权利。
Ovalbumin is a protein of unknown function found in large quantities in avian egg-white. Surprisingly, ovalbumin belongs to the serpin family although it lacks any protease inhibitory activity. We review here what is known about the amino acid sequence, post-translational modifications and tertiary structure of ovalbumin. The properties of ovalbumin are discussed in relation to their possible functional significance. These include reasons for failure of ovalbumin to undergo a typical serpin conformational change involving the reactive centre loop, which explains why ovalbumin is not a protease inhibitor, and also the natural conversion of ovalbumin to the more stable "S" form. (C) 2001 Elsevier Science B.V. All rights reserved.