Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids
Combining two-directional synthesis and tandem reactions. Part 4: A concise approach to the spirocyclic core of halichlorine and the pinnaic acids
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DOI：
10.1016/j.tetlet.2004.09.058
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发表时间：
2004-11-01
影响因子：
1.8
通讯作者：
Stockman, RA
中科院分区：
文献类型：
--
作者：
Arini, LG;Szeto, P;Stockman, RA
本文介绍了VCAM-1诱导表达抑制剂卤氯啉和PLA抑制剂羽叶酸的螺环核心结构的合成。采用双向策略，结合串联肟形成/迈克尔加成/环加成以非常直接的方式形成关键的氮杂螺环骨架。(C)2004爱思唯尔有限公司保留所有权利。
A synthesis of the spirocyclic core structure of halichlorine, an inhibitor of the induced expression of VCAM-1 and the pinnaic acids, inhibitors of PLA(2), is presented. A two-directional strategy is employed, in conjunction with a tandem oxime formation/Michael addition/cycloaddition to form the key azaspirocyclic skeleton in a very direct manner. (C) 2004 Elsevier Ltd. All rights reserved.