Dioxins and dibenzofurans in adipose tissue of US Vietnam veterans and controls.
Dioxins and dibenzofurans in adipose tissue of US Vietnam veterans and controls.
复制标题
美国越战退伍军人和控制人员脂肪组织中的二恶英和二苯并呋喃。
DOI：
10.2105/ajph.81.3.344
复制
发表时间：
1991
影响因子：
12.7
通讯作者：
M. Flicker
中科院分区：
文献类型：
--
作者：
H K Kang;K. Watanabe;J. Breen;J. Remmers;M G Conomos;J. Stanley;M. Flicker
对接触橙子剂的不利影响感到关切的主要原因是其有毒污染物，2，3，7，8-四氯二苯并对二恶英（TCDD）或二恶英。我们研究了36名越战老兵、79名非越战老兵和80名平民的脂肪组织;组织标本选自美国环境保护局从非机构化的普通人群中收集的8,000份存档组织。在脂肪组织中，越战老兵、非越战老兵和平民对照组的几何平均（+/-标准差）二恶英水平分别为11.7（+/- 1.7）、10.9（+/- 1.7）和12.4（+/- 1.9）万亿分之一（基于脂质重量）。在调整或不调整个体年龄、体重指数和标本采集年份的情况下，这些组的平均水平彼此之间无显著差异。此外，代理橙子剂暴露的替代措施，如军事分支机构，在特定地理区域内的服务，军事占领，和部队的位置记录的橙子剂喷雾与越南退伍军人的脂肪组织中的二恶英水平。我们的研究结果表明，大多数美军不太可能大量接触橙子剂或二恶英。
The primary reason for concern about the adverse effects of exposure to Agent Orange is attributable to its toxic contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or dioxin. We studied adipose tissues from 36 Vietnam veterans, a similar group of 79 non-Vietnam veterans, and 80 civilians; the tissue specimens were selected from the 8,000 archived tissues collected from the non-institutionalized general population by the US Environmental Protection Agency. The geometric mean (+/- standard deviation) dioxin levels in adipose tissue for Vietnam veterans, non-Vietnam veterans, and civilian controls were 11.7 (+/- 1.7), 10.9 (+/- 1.7), and 12.4 (+/- 1.9) parts per trillion on a lipid weight basis, respectively. The mean levels for these groups were not significantly different from each other with or without adjustment for age of individuals, body mass index, and specimen collection year. In addition, none of the surrogate measures of Agent Orange exposure such as military branch, service within specific geographic region, military occupation, and troop location in relation to recorded Agent Orange spray was associated with the dioxin levels in adipose tissue of Vietnam veterans. Our results suggest that heavy exposure to Agent Orange or dioxin for most US troops was unlikely.