Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces.
Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces.
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DOI：
10.1155/2016/3827684
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发表时间：
2016
影响因子：
4.6
通讯作者：
Riboni L
中科院分区：
文献类型：
--
作者：
Abdel Hadi L;Di Vito C;Riboni L
复合鞘磷脂是肠膜的基本结构成分，为肠粘膜提供保护和完整性，并调节肠道吸收过程。鞘磷脂信号在许多细胞事件中的作用已经确立，包括肠道细胞的生存、生长、分化和凋亡。大量的知识表明，肠鞘磷脂在免疫和炎症性疾病中发挥着关键作用，并通过它们的信号通路发挥着关键作用。在这篇综述中，我们报道并讨论了鞘脂在炎症性肠病(IBD)中的代谢、信号转导和功能意义，重点介绍了鞘脂在炎症反应中作用的不同方面，以及鞘脂靶向分子作为抗IBD治疗剂的潜力。
Complex sphingolipids are essential structural components of intestinal membranes, providing protection and integrity to the intestinal mucosa and regulating intestinal absorption processes. The role of sphingolipid signaling has been established in numerous cellular events, including intestinal cell survival, growth, differentiation, and apoptosis. A significant body of knowledge demonstrates that intestinal sphingolipids play a crucial role, as such and through their signaling pathways, in immunity and inflammatory disorders. In this review, we report on and discuss the current knowledge on the metabolism, signaling, and functional implications of sphingolipids in inflammatory bowel disease (IBD), focusing on the different aspects of sphingolipid actions on inflammatory responses and on the potential of sphingolipid-targeted molecules as anti-IBD therapeutic agents.