Sleep and circadian rhythms in mood disorders
Sleep and circadian rhythms in mood disorders
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DOI：
10.1111/j.1600-0447.2007.00968.x
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发表时间：
2007-01-01
影响因子：
6.7
通讯作者：
Armitage, R.
中科院分区：
文献类型：
--
作者：
Armitage, R.
目的：超过 80% 的抑郁症患者自我报告存在睡眠障碍。然而，基于夜间多导睡眠图的睡眠脑电图（EEG）结果并不总能区分抑郁症患者和健康个体。方法：本文将回顾抑郁症睡眠脑电图研究的结果，强调最新的技术和方法进步对研究结果的影响。结果：大多数研究，包括我们自己的工作，确实表明抑郁症患者的睡眠稳态和睡眠脑电图节律异常，但 睡眠障碍很大程度上受到性别和年龄的影响。在抑郁男性中，抑郁症的忧郁特征与低慢波活动显着相关，但在抑郁女性中则不然。患有抑郁症的女性睡眠脑电图节律的时间一致性较低，但忧郁特征的存在或不存在并不影响相关性。结论：抑郁症的诊断分类模式和临床特征可能会影响睡眠脑电图结果，但性别可能是更重要的考虑因素。
Objective: Self-reported sleep disturbances are present in over 80% of patients with depression. However, sleep electroencephalography (EEG) findings, based on overnight polysomnography have not always differentiated depressed patients from healthy individuals.Method: The present paper will review the findings on sleep EEG studies in depression highlighting how recent technological and methodological advances have impacted on study outcomes.Results: The majority of studies, including our own work, do indicate that sleep homeostasis and sleep EEG rhythms are abnormal in depression, but the sleep disturbances were strongly moderated by gender and age. Melancholic features of depression correlated significantly with low slow-wave activity in depressed men, but not in depressed women. Women with depression showed low temporal coherence of sleep EEG rhythms but the presence or absence of melancholic features did not influence correlations.Conclusion: Diagnostic classification schemas and clinical features of depression may influence sleep EEG findings, but gender may be a more important consideration.