Alcoholic liver disease: From pathophysiology to therapy
Alcoholic liver disease: From pathophysiology to therapy
复制标题
DOI：
10.1097/01.alc.0000171896.37022.f7
复制
发表时间：
2005-07-01
影响因子：
3.2
通讯作者：
Horie, Y
中科院分区：
文献类型：
--
作者：
Seitz, HK;Lieber, CS;Horie, Y
本文介绍了2004年10月在曼海姆，德国举行的国际酒精中毒生物医学研究学会会议上举行的专题讨论会的会议记录。本次研讨会的一个突出特点是展示了我们对酒精性肝病病理生理学的理解所取得的惊人进展如何提高了更好治疗的前景。遗传因素正在被阐明，F。斯蒂克尔（德国）总结了他自己和其他人的研究。M. Salaspuro（芬兰）更新了肠道细菌在酒精性肝病发病机制中的可能作用，使我们更接近抗菌治疗作为酒精性肝病治疗的一部分。具体地，肠道细菌植物群可能通过乙醛的原位产生和相关的肠损伤而重要，这可能有利于毒素从肠腔转移到体循环和肝脏。本文综述了H。P. Schlemmer（德国）可能最终为我们提供了一种客观的方法来识别可能需要磷脂治疗的患者。其他治疗重度酒精性肝炎的新方法由Y. Horie和H.石井（日本），包括血浆置换。最后，C。S. Lieber博士证明，尽管一些营养保健品可能会因酒精而加剧毒性，必须在狭窄的治疗窗口内非常小心地服用，但其他营养保健品在受控条件下实际上是有益的。
This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism in Mannheim, Germany, in October 2004. A salient feature of this symposium was to demonstrate how the striking advances made in our understanding of the pathophysiology of alcoholic liver disease are now raising prospects for better treatment as well. Genetic factors are now being elucidated, and F. Stickel (Germany) has summarized his own studies as well as those of others. M. Salaspuro (Finland) updated the possible role of gut bacteria in the pathogenesis of alcoholic liver disease, bringing us closer to antibacterial therapy as part of the treatment of alcoholic liver disease. Specifically, the gut bacterial flora may be important via the in situ production of acetaldehyde and the associated intestinal injury, which may favor the translocation of toxins from the gut lumen to the systemic circulation and the liver. The analytical progress in the assessment of alterations of phospholipid composition in liver membranes described by H. P. Schlemmer (Germany) may eventually give us an objective method to recognize patients in whom phospholipid therapy might be indicated. Other novel treatment modalities for severe alcoholic hepatitis were described by Y. Horie and H. Ishii (Japan), including plasma exchange. Finally, the pros and cons of nutraceutical therapy were analyzed by C. S. Lieber, with a demonstration that although some nutraceuticals may have toxicity exacerbated by alcohol and must be administered very carefully within a narrow therapeutic window, others are actually beneficial as demonstrated under controlled conditions.