Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin
Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin
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DOI：
10.1007/s00604-020-4206-y
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发表时间：
2020-03-12
影响因子：
5.7
通讯作者：
Erk, Nevin
中科院分区：
文献类型：
--
作者：
Er, Engin;Erk, Nevin
提出了一种基于金属相MoS 2（1 T-MoS 2）修饰有形状依赖性金纳米结构的电化学传感器的创新和便携式设计，用于测定多柔比星（DOX）。在此背景下，同质和均匀的单晶金纳米球（AuNSPs）和纳米棒（AuNRDs）首次合成的种子生长方法。然后，将AuNSP和AuNRD锚定在1 T-MoS 2表面上以构建针对DOX测定的所需电化学传感平台。采用NaK金属合金对1 T-MoS 2进行金属插层剥离。采用XPS、拉曼、UV-vis、TEM和SEM等手段对1 T-MoS 2、AuNSPs和AuNRDs的结构和表面形貌进行了表征。采用循环伏安法和吸附溶出微分脉冲伏安法研究了在丝网印刷电极上制备的各种MoS 2基电化学传感器对DOX的电化学行为。比较了AuNRDs和AuNSPs在1 T-MoS 2上对DOX的电催化活性，发现AuNRDs对DOX的电催化活性更高。用AuNRDs和1 T-MoS 2在SPE上制备的纳米复合物（AuNRDs/1 T-MoS 2/SPE）在0.01-9.5 μ M范围内表现出峰电流与DOX浓度之间的线性关系，检测限为2.5 nM。该方法用于人血清中阿霉素的测定，回收率在99.2- 100.8%之间。
An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS2 (1T-MoS2) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS2 surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS2 was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS2, AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS2-based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS2 was also compared with that of AuNSPs on 1T-MoS2, and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS2 on SPE (AuNRDs/1T-MoS2/SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01-9.5 mu M with a detection limit of 2.5 nM. The AuNRDs/1T-MoS2/SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2-100.8%.