EFFECT OF NEUROPEPTIDES ON PRODUCTION OF INFLAMMATORY CYTOKINES BY HUMAN-MONOCYTES
EFFECT OF NEUROPEPTIDES ON PRODUCTION OF INFLAMMATORY CYTOKINES BY HUMAN-MONOCYTES
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DOI：
10.1126/science.2457950
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发表时间：
1988-09-02
期刊：
影响因子：
56.9
通讯作者：
CARSON, DA
中科院分区：
文献类型：
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作者：
LOTZ, M;VAUGHAN, JH;CARSON, DA
两组介质，神经肽物质P和K和单核细胞衍生的细胞因子，在免疫和炎症反应的神经调节中相互作用。P物质、K物质和羧基末端肽SP（4-11）诱导白细胞介素-1、肿瘤坏死因子-α、和白细胞介素-6。神经肽效应发生在低剂量下，如P物质拮抗剂的抑制研究所示具有特异性，并且需要从头蛋白质合成。由于单核细胞衍生的细胞因子调节炎症和免疫中的多种细胞功能，并且由于神经肽可以从外周神经末梢释放到周围组织中，这些发现确定了神经系统调节宿主防御反应的有效机制。
Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived cytokines, interact in the neural regulation of immunological and inflammatory responses. Substance P, substance K, and the carboxyl-terminal peptide SP(4-11) induce the release of interleukin-1, tumor necrosis factor-.alpha., and interleukin-6 from human blood monocytes. The neuropeptide effects occur at low doses, are specific as shown by inhibition studies with a substance P antagonist, and require de novo protein synthesis. Since monocyte-derived cytokines regulate multiple cellular functions in inflammation and immunity and since neuropeptides can be released from peripheral nerve endings into surroundings tissues, these findings identify a potent mechanism for nervous system regulation of host defense responses.