Increases in extracellular fluid glucose levels in the rat hippecampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study
Increases in extracellular fluid glucose levels in the rat hippecampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study
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DOI：
10.1016/j.physbeh.2004.11.009
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发表时间：
2005-02-15
影响因子：
2.9
通讯作者：
Gold, PE
中科院分区：
文献类型：
--
作者：
Canal, CE;McNay, EC;Gold, PE
使用体内微透析，我们检查了葡萄糖水平的细胞外液（ECF）的海马和血液之前和期间戊巴比妥（45毫克/公斤）或氯胺酮-甲苯噻嗪（66毫克/公斤，7毫克/公斤）麻醉。戊巴比妥或氯胺酮-甲苯噻嗪麻醉显著增加海马ECF葡萄糖水平（平均峰值分别增加+71%和+85%）。此外，血糖水平显著升高（平均峰值分别升高+24%和+30%）。在麻醉过程中海马ECF葡萄糖水平的增加补充了过去的证据，减少ECF葡萄糖在海马中观察到，而大鼠执行记忆任务海马损伤敏感，提供了进一步的支持，认为ECF葡萄糖水平在海马动态耦合到本地神经活动。(c)2004年爱思唯尔公司All rights reserved.
Using in vivo microdialysis, we examined glucose levels in the extracellular fluid (ECF) of the hippocampus and in the blood prior to and during pentobarbital (45 mg/kg) or ketamine-xylazine (66 mg/kg, 7 mg/kg) anesthesia. Anesthesia with either pentobarbital or ketamine-xylazine significantly increased hippocampal ECF glucose levels (mean peak increases of +71% and +85%, respectively). In addition, there were substantial increases in blood glucose levels (mean peak increases of +24% and +30%, respectively). The increased levels of hippocampal ECF glucose during anesthesia complement past evidence for decreases in ECF glucose in the hippocampus observed while rats perform a memory task sensitive to hippocampal damage, providing further support for the view that ECF glucose levels in the hippocampus are dynamically coupled to local neural activity. (c) 2004 Elsevier Inc. All rights reserved.