Mood Response to Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
Mood Response to Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
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DOI：
10.1176/appi.neuropsych.11030060
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发表时间：
2012-12-01
影响因子：
2.9
通讯作者：
Hershey, Tamara
中科院分区：
文献类型：
--
作者：
Campbell, Meghan C.;Black, Kevin J.;Hershey, Tamara
帕金森病（PD）患者丘脑底核脑深部刺激（DBS）可改善运动功能，但对情绪有不同的影响。很少有人知道电极接触位置和情绪反应之间的关系。作者确定了电极接触的解剖位置，并使用视觉模拟量表测量了24例DBS PD患者对刺激的情绪反应。参与者报告了更积极的情绪和减少焦虑和冷漠的双边和单边刺激。左侧DBS改善情绪的效果优于右侧DBS。右侧DBS诱导的积极情绪增加与更多的内侧和背侧接触位置有关。这些结果突出了功能的异质性的神经元。
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) improves motor functioning but has variable effects on mood. Little is known about the relationship between electrode contact location and mood response. The authors identified the anatomical location of electrode contacts and measured mood response to stimulation with the Visual Analog Scale in 24 STN DBS PD patients. Participants reported greater positive mood and decreased anxiety and apathy with bilateral and unilateral stimulation. Left DBS improved mood more than right DBS. Right DBS-induced increase in positive mood was related to more medial and dorsal contact locations. These results highlight the functional heterogeneity of the STN.