Commentary on Improving Biospecimen Utilization by Classic Biobanks: Identifying Past and Minimizing Future Mistakes
Commentary on Improving Biospecimen Utilization by Classic Biobanks: Identifying Past and Minimizing Future Mistakes
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DOI：
10.1089/bio.2018.0080
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发表时间：
2019-06-01
影响因子：
1.6
通讯作者：
Sexton, Katherine C.
中科院分区：
文献类型：
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作者：
Grizzle, William E.;Sexton, Katherine C.
许多传统的生物库收集的人体组织比分发的多，导致库存增加，不必要的存储，费用增加，按存储容量使用计费收入减少。造成这种情况的原因是生物库的运作没有明确的目标，对将利用标本的调查人员的潜在人数有不正确的看法，以及在没有充分考虑调查人员对特定组织的需要的情况下收集生物标本。这些不足经常导致不切实际的生物菌素利用计划和超出必要的生物库。例如，组织收集通常不会定期与生物素分布进行比较并进行相应的修改。对于同意患者在研究中使用他们的组织的可接受性，出现了一个伦理问题，而没有一个现实的有计划的方法来分配生物标本，并最终将其用于支持生物医学研究。这些问题以及如何最大限度地减少这些问题在这篇评论中进行了讨论，重点是传统生物库如何提高其生物谱系的利用率。
Many classic biobanks collect more human tissues than they distribute, leading to increased inventories, unnecessary storage, increased expenses, and reduced chargeback income. This situation is a result of biobanks operating without well-defined goals, having incorrect views of the potential number of investigators who will utilize specimens, and collection of biospecimens without adequately considering the need for specific tissues by investigators. These deficiencies frequently lead to unrealistic plans for biospecimen utilization and biobanks that are larger than necessary. For example, tissue collections usually are not periodically compared with biospecimen distribution and modified accordingly. An ethical issue has arisen as to the acceptability of consenting patients for the use of their tissues in research without a realistic planned approach to distribution of the biospecimens and their ultimate utilization in supporting biomedical research. These issues and how to minimize them are discussed in this commentary focused on how classic biobanks can improve utilization of their biospecimens.