CARDIOVASCULAR-DISEASE AND DISTRIBUTION OF COGNITIVE FUNCTION IN ELDERLY PEOPLE - THE ROTTERDAM STUDY
CARDIOVASCULAR-DISEASE AND DISTRIBUTION OF COGNITIVE FUNCTION IN ELDERLY PEOPLE - THE ROTTERDAM STUDY
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DOI：
10.1136/bmj.308.6944.1604
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发表时间：
1994-06-18
影响因子：
--
通讯作者：
HOFMAN, A
中科院分区：
文献类型：
--
作者：
BRETELER, MMB;CLAUS, JJ;HOFMAN, A
研究老年人认知功能的分布，并评估动脉粥样硬化疾病的临床表现对这种分布的影响。设计-单中心人群为基础的横断面门到门研究。设置-Ommoord，荷兰鹿特丹的郊区。受试者-4971名年龄在55至94岁的受试者。主要结果测量-认知功能的微型精神状态examination.Results-the总体参与率在研究中是80%。认知测试数据可用于90%的参与者。年龄增长和教育水平较低与认知功能较差有关。既往血管事件、颈动脉斑块和外周动脉粥样硬化性疾病与认知能力较差相关，与年龄和教育程度无关。平均而言，这些差异是中等的;然而，它们反映了认知功能的总人口分布向低值转移的净结果。因此，他们导致了显着增加的受试者的分数指示dementions. Conclusions的比例，这些研究结果是兼容的观点，即动脉粥样硬化性疾病占相当大的认知功能障碍，在一般人群。
Objective-To investigate the distribution of cognitive function in elderly people and to assess the impact of clinical manifestations of atherosclerotic disease on this distribution.Design-Single centre population based cross sectional door to door study.Setting--Ommoord, a suburb of Rotterdam, the Netherlands.Subjects-4971 subjects aged 55 to 94 years. Main outcome measure-Cognitive function as measured by the mini mental state examination.Results-The overall participation rate in the study was 80%. Cognitive test data were available for 90% of the participants. Increasing age and lower educational level were associated with poorer cognitive function. Previous vascular events, presence of plaques in the carotid arteries, and presence of peripheral arterial atherosclerotic disease were associated with worse cognitive performance independent of the effects of age and education. On average the differences were moderate; however, they reflected the net result of a shift of the total population distribution of cognitive function towards lower values. Thereby, they resulted in a considerable increase in the proportion of subjects with scores indicative of dementia.Conclusions-These findings are compatible with the view that atherosclerotic disease accounts for considerable cognitive impairment in the general population.