AMPLIFICATION OF N-MYC IN UNTREATED HUMAN NEUROBLASTOMAS CORRELATES WITH ADVANCED DISEASE STAGE
AMPLIFICATION OF N-MYC IN UNTREATED HUMAN NEUROBLASTOMAS CORRELATES WITH ADVANCED DISEASE STAGE
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DOI：
10.1126/science.6719137
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
BISHOP, JM
中科院分区：
文献类型：
--
作者：
BRODEUR, GM;SEEGER, RC;BISHOP, JM
一种被称为N-霉菌的DNA结构域，在人神经母细胞瘤细胞系中扩增20至140倍，但在其他肿瘤类型的细胞系中不扩增。在63名未经治疗的患者中，有24名（38%）的神经母细胞瘤组织中发现了N-mychas扩增。扩增的程度似乎是双峰，在12例中扩增100至300倍，在10例中扩增3至10倍。在15例1期或2期患者中发现0例扩增，而48例3期或4期患者中有24例（50%）有N-支原体扩增的证据。这些数据表明，N-支原体化是一个共同的事件，在未经治疗的人类神经母细胞瘤。此外，N-支原体化与疾病的晚期（P < 0.001）和作为已建立的细胞系在体外生长的能力高度相关，这两者都与不良预后相关。
A domain of DNA designated N-mycis amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-mychas now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimodal, with amplification of 100- to 300-fold in 12 cases and 3- to 10-fold in 10 others. Amplification was found in 0 of 15 patients with stage 1 or 2 disease, whereas 24 of 48 cases (50 percent) with stage 3 or 4 had evidence of N-mycamplification. These data indicate that N-mycamplification is a common event in untreated human neuroblastomas. Furthermore, N-mycamplification is highly correlated with advanced stages of disease (P < 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis.