INVITRO SUSCEPTIBILITY OF CLOSTRIDIUM-DIFFICILE ISOLATES FROM PATIENTS WITH ANTIBIOTIC-ASSOCIATED DIARRHEA OR COLITIS
INVITRO SUSCEPTIBILITY OF CLOSTRIDIUM-DIFFICILE ISOLATES FROM PATIENTS WITH ANTIBIOTIC-ASSOCIATED DIARRHEA OR COLITIS
复制标题
DOI：
10.1128/aac.17.4.695
复制
发表时间：
1980-01-01
影响因子：
4.9
通讯作者：
BARTLETT, JG
中科院分区：
文献类型：
--
作者：
DZINK, J;BARTLETT, JG
对84株念珠菌进行了体外药敏试验。对11种抗菌药物敏感。所有分离株均来自抗生素相关腹泻或结肠炎患者的粪便，其中含有被C中和的细胞病变毒素。黑粪菌抗毒素超过95%的菌株对浓度为4 μ g/ml的万古霉素、青霉素G、氨苄青霉素和甲硝唑敏感。对克林霉素的敏感性是可变的; 60%的菌株在1 μ g/ml时敏感，9%在128 μ g/ml时耐药。对单个分离株的研究表明，大部分菌株对引起疾病的抗菌剂相对敏感。
In vitro susceptibility tests were performed on 84 strains of C. difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by C. sordellii antitoxin. Over 95% of the strains were susceptible to vancomycin, penicillin G, ampicillin and metronidazole at concentrations of 4 .mu.g/ml. Susceptibility to clindamycin was variable; 60% of the strains were susceptible at 1 .mu.g/ml, and 9% were resistant at 128 .mu.g/ml. Studies of individual isolates showed that a major portion of the strains were relatively susceptible to the antimicrobial agent implicated in causing the disease.