The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: The Multi-Ethnic Study of Atherosclerosis (MESA)
The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: The Multi-Ethnic Study of Atherosclerosis (MESA)
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DOI：
10.1016/j.atherosclerosis.2006.08.002
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发表时间：
2007-09-01
期刊：
影响因子：
5.3
通讯作者：
Jacobs, David R.
中科院分区：
文献类型：
--
作者：
Holvoet, Paul;Jenny, Nancy S.;Jacobs, David R.
一些研究小组已经证明，已知的冠心病与氧化低密度脂蛋白 (oxLDL) 升高之间存在关联。与心血管危险因素和亚临床CVD的关系尚不清楚。因此，我们在动脉粥样硬化队列多种族研究中检查了这种关联：对 879 名没有 CHID 的人（所有非他汀类药物使用者）进行了横断面检查。 oxLDL 使用基于 4E6 的单克隆抗体 ELISA 进行测量。亚临床 CVD 的存在被定义为颈动脉中出现斑块且狭窄≥25，踝臂血压指数 (ABI) = 200。在多变量模型中，血脂异常（胆固醇、高密度脂蛋白胆固醇、甘油三酯水平不良）、炎症（纤维蛋白原升高）、性别（男性）、种族（黑人）、 目前吸烟解释了 oxLDL 的最大变异（模型 R-2 = 0.41）。在双变量分析中，亚临床 CVD 患者的 oxLDL 水平较高（1.22 mg/dl 对比 0.95 mg/dl；P = 0.0002）。对危险因素的调整与亚临床 CVD 的减弱相关性相关（P = 0.026）。总之，oxLDL 通过与许多心血管危险因素的关系而与亚临床 CVD 相关。 (C) 2006 Elsevier Ireland Ltd. 保留所有权利。
Several groups have demonstrated an association between established CHD and elevated oxidized LDL (oxLDL). The relation with cardiovascular risk factors and subclinical CVD is less clear. Therefore, we examined this association in the Multi-Ethnic Study of Atherosclerosis cohort: 879 persons without CHID, all non-statin users, examined cross-sectionally. oxLDL was measured with a monoclonal antibody 4E6-based ELISA. The presence of subclinical CVD was defined as plaque occurrence in carotid arteries with >= 25 stenosis, ankle-brachial blood pressure index (ABI) = 200. In a multivariate model, dyslipidernia (adverse levels of cholesterol, HDL-cholesterol, triglycerides), inflammation (elevated fibrinogen), gender (male), ethnicity (Black), and current smoking explained the most variation in oxLDL (model R-2 = 0.41). In bivariate analyses, persons with subclinical CVD had higher levels of oxLDL (1.22 mg/dl versus 0.95 mg/dl; P = 0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P = 0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors. (C) 2006 Elsevier Ireland Ltd. All rights reserved.