Usefulness of adenosine for arrhythmias in infants and children.
Usefulness of adenosine for arrhythmias in infants and children.
复制标题
腺苷对婴儿和儿童心律失常的有用性。
DOI：
10.1016/0002-9149(88)90940-x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
DiMarco,JP
中科院分区：
文献类型：
--
作者：
Overholt,ED;Rheuban,KS;Gutgesell,HP;Lerman,BB;DiMarco,JP
25名婴儿和儿童（11名患者出现持续性心律失常后，14名患者在诊断性电生理研究期间）接受腺苷治疗，以确定其电生理效应。腺苷静脉推注给药（起始剂量为37.5 μg/kg，以37.5 μg/kg的增量增加，直至观察到效果）。腺苷引起心动过速终止或短暂增加房室（AV）阻滞在所有25例患者。7名患者出现仅需心房维持的心动过速，并出现房室结阻滞增加（最小有效腺苷剂量范围为37.5至350 μg/kg，平均131）。13例出现房室折返性心动过速或房室结折返性心动过速（最小有效腺苷剂量范围37.5 - 225 μg/kg，平均114）。另外4名患者接受腺苷治疗以排除预激（最小有效腺苷剂量范围为37.5至375 μg/kg，平均165）。25例患者中有1例出现交界性异位心动过速，腺苷给药引起逆行性房室传导阻滞。25例中有6例（24%）有明显但轻微的副作用。1例患者出现持续性心动过缓（2 - 3分钟，需要临时起搏）。腺苷是评估和治疗婴儿和儿童心律失常的安全有效药物。
Adenosine was administered to 25 infants and children (11 patients after presenting with a sustained arrhythmia, and 14 during a diagnostic electrophysiologic study) to determine its electrophysiologic effects. Adenosine was given as an intravenous bolus (starting dose 37.5 μg/kg, and increased by 37.5 μg/kg increments until an effect was seen). Adenosine caused tachycardia termination or transient increased atrioventricular (AV) block in all 25 patients. Seven patients had tachycardia requiring only the atria for perpetuation and developed increased AV nodal block (minimum effective adenosine dose range 37.5 to 350 μg/kg, mean 131). Thirteen had AV reciprocating tachycardia or AV node reentry tachycardia (minimum effective adenosine dose range 37.5 to 225 μg/kg, mean 114). Four other patients received adenosine to rule out preexcitation (minimum effective adenosine dose range 37.5 to 375 μg/kg, mean 165). One of the 25 patients had junctional ectopic tachycardia and adenosine administration caused retrograde AV block. Six of the 25 (24%) had noticeable but minor side effects. One patient had sustained bradycardla (2 to 3 minutes requiring temporary pacing). Adenosine is a safe and effective agent in the evaluation and treatment of infants and children with arrhythmias.