Elevated macrophage activity in nude mice.
Elevated macrophage activity in nude mice.
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裸鼠巨噬细胞活性升高。
DOI：
10.1159/000163231
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Colston
中科院分区：
文献类型：
--
作者：
A. Sharp;M. Colston
有大量证据表明，尽管缺乏T细胞介导的免疫机制，裸鼠仍能够控制肿瘤的发展和细胞内微生物的生长。例如，裸鼠的肿瘤发生率与提供裸基因背景的近交株相当[5]，并且裸鼠在某些情况下已被证明对单核细胞增生李斯特氏菌[2]和白色念珠菌[1]的感染具有更强的抵抗力。迄今为止，巨噬细胞的作用以及 T 细胞缺乏在这些免疫机制中的影响仍未阐明。我们检查了裸鼠和正常小鼠腹膜巨噬细胞活性的许多参数，并确定了用来自同基因供体的 T 细胞或胸腺组织重建裸鼠的效果。此外，我们还确定了裸鼠微生物状态对巨噬细胞活化程度的影响。
There is considerable evidence to show that in spite of the lack of T cell-mediated immune mechanisms nude mice are able to control the development of tumours and the growth of intracellular micro-organisms. For example, tumour incidence in nudes is comparable to that of the inbred strain providing the background for the nude gene [5] and nude mice have been shown under certain circumstances to be more resistant to infection with Listeria monocytogenes [2] and Candida albicans [1]. Hitherto the role of the macrophage and the implications of the lack of T cells in these im-mune mechanisms has remained unelucidat-ed. We have examined a number of param-eters of peritoneal macrophage activity in both nude and normal mice and we have determined the effect of reconstitution of nude mice with either T cells or thymus tissue derived from syngeneic donors. In addition, we have determined the effect of the microbiological status of the nude mouse upon the degree of macrophage activation.