INSULIN-LIKE GROWTH-FACTORS AND THE LOCAL-REGULATION OF BONE-FORMATION
INSULIN-LIKE GROWTH-FACTORS AND THE LOCAL-REGULATION OF BONE-FORMATION
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DOI：
10.1016/8756-3282(93)90151-y
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发表时间：
1993-05-01
期刊：
影响因子：
4.1
通讯作者：
CANALIS, E
中科院分区：
文献类型：
--
作者：
CANALIS, E
生长因子是已知影响骨骼和非骨骼细胞的生长和分化功能的多肽。骨骼肌细胞合成多种生长因子，并且胰岛素样生长因子（IGF）I和II是由这些细胞合成的最普遍的因子（Canalis等人，1991年）。IGF I和II是分子量约为7600的多肽，可调节骨骼和非骨骼细胞中的多种代谢功能（Daughthorn和Rotwein 1989）。尽管在骨细胞中，IGF I比IGF II更有效，但IGF I和II具有相似的生物活性。IGF刺激成骨细胞谱系的细胞（可能是前成骨细胞）的复制并刺激胶原合成和基质附着速率（Hock等人，1988年）。对基质合成的影响独立于IGF对细胞复制的作用，并且似乎是继发于成骨细胞的I型胶原转录的增加（McCarthy等人，1989年a）。IGF还通过仍然未知的机制减少胶原降解，并且IGF I而不是IGF II增强骨再吸收细胞（可能是破骨细胞）的募集（Mochizuki等人，1992年）。IGF存在于体循环中，在那里它们与IGF结合蛋白（IGFBP）和酸不稳定亚基结合，形成大分子量复合物。IGF也由多种骨骼和非骨骼细胞系统分泌，并被认为是细胞生长的全身和局部调节剂。控制全身和局部IGF I产生的机制可能不同。全身性IGF I主要来源于肝细胞，并且受生长激素控制，而局部产生的I= I受各种激素和生长因子控制，这些激素和生长因子在各种c&l系统中不同。
Growth factors are polypeptides known to affect the growth and differentiated function of skeletal and nonskeletal cells. Skeletal cells synthesize a variety of growth factors, and insulin-like growth factor (IGF) I and II are among the most prevalent factors synthesized by these cells (Canalis et al., 1991). IGF I and II, polypeptides with an approximate molecular mass of 7600, regulate a variety of metabolic functions in skeletal and nonskeletal cells (Daughaday and Rotwein 1989). IGF I and II have similar biological activities although in bone cells IGF I is somewhat more potent than IGF II. IGFs stimulate the replica&m of cells of the osteoblastic lineage, likely preosteoblasts and stimulate collagen synthe&s and matrix apposition rates (Hock et al., 1988). The effect on matrix synthesis is independent from IGF actions on cell replication, and it appears to be secondary to an increase in type I collagen transcription by the osteoblast (McCarthy et al., 1989a). IGFs also decrease collagen degradation by mechanisms that are still unknown, and IGF I, but not IGF II, enhances the recruitment of bone resorbing cells, likely osteoclasts (Mochizuki et al., 1992). It is therefore apparent that IGFs have important actions on cells of the skeletal system and as such they are considered essential regulators of bone remodeling.IGFs are present in the systemic circulation, where they sre bound to IGF’binding proteins (IGFBP) and to an acid labile subunit, forming a large molecular weight complex. IGFs are also secreted by a variety of skeletal and nonskeletal cell systems and are considered to act as systemic and local regulators of cell growth. The ‘mechanisms controlling the production of systemic and local IGF I sre likely different. Systemic IGF I is primarily derived from liver cells and it is under growth hormone control, whereaslocally produced I= I is controlled by a variety of hormones and growth factors which differ in various c&l systems.