Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study.
Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study.
复制标题
DOI：
10.1038/srep21090
复制
发表时间：
2016-02-12
影响因子：
4.6
通讯作者：
Cheng CY
中科院分区：
文献类型：
--
作者：
Agrawal R;Gupta P;Tan KA;Cheung CM;Wong TY;Cheng CY
脉络膜的血管性与各种眼病的发病机制有关。到目前为止，还没有确定的可量化的参数来估计脉络膜的血管状态。脉络膜血管指数（CVI）可能用于评估脉络膜的血管状态。我们的目的是建立CVI的规范数据库，并确定与CVI相关的因素。在这项以345只健康眼睛为基础的人群研究中，采用改进的图像二值化技术对脉络膜增强深度成像光学相干断层扫描进行分割。总中央凹下脉络膜区（TCA）分为管腔区（LA）和间质区（SA）。CVI计算为LA与TCA的比例。线性回归用于识别与CVI和中央凹下脉络膜厚度（SFCT）相关的眼部和全身因素。中央凹下CVI范围为60.07 ~ 71.27%，平均值为65.61±2.33%。CVI的变化小于SFCT （CVI的变异系数为3.55 vs SFCT的40.30）。较高的CVI与较厚的SFCT相关，但与大多数生理变量无关。CVI是SFCT的重要决定因素。虽然SFCT受到许多因素的影响，但CVI不受影响，这表明CVI是脉络膜疾病更强大的标志物。
The vascularity of the choroid has been implicated in the pathogenesis of various eye diseases. To date, no established quantifiable parameters to estimate vascular status of the choroid exists. Choroidal vascularity index (CVI) may potentially be used to assess vascular status of the choroid. We aimed to establish normative database for CVI and identify factors associated with CVI in healthy eyes. In this population-based study on 345 healthy eyes, choroidal enhanced depth imaging optical coherence tomography scans were segmented by modified image binarization technique. Total subfoveal choroidal area (TCA) was segmented into luminal (LA) and stromal (SA) area. CVI was calculated as the proportion of LA to TCA. Linear regression was used to identify ocular and systemic factors associated with CVI and subfoveal choroidal thickness (SFCT). Subfoveal CVI ranged from 60.07 to 71.27% with a mean value of 65.61 ± 2.33%. CVI was less variable than SFCT (coefficient of variation for CVI was 3.55 vs 40.30 for SFCT). Higher CVI was associated with thicker SFCT, but not associated with most physiological variables. CVI was elucidated as a significant determinant of SFCT. While SFCT was affected by many factors, CVI remained unaffected suggesting CVI to be a more robust marker of choroidal diseases.