The role of uncoupling proteins in diabetes mellitus.
The role of uncoupling proteins in diabetes mellitus.
复制标题
解偶联蛋白在糖尿病中的作用
DOI：
10.1155/2013/585897
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发表时间：
2013
影响因子：
4.3
通讯作者：
Wang CM
中科院分区：
文献类型：
--
作者：
Liu J;Li J;Li WJ;Wang CM
解偶联蛋白（Uncoupling Proteins，UCPs）是一种在线粒体内膜上表达的阴离子载体，它将呼吸链的氧消耗与ATP合成解偶联。自从新的UCPs（UCPs 2~5）被发现以来，UCPs的生理功能一直备受争议，其中UCPs在糖尿病发病机制中的作用是最热门的话题之一。UCPs被认为被超氧化物激活，然后减少线粒体自由基的产生;这可能对氧化应激条件下的糖尿病提供保护作用。UCP1由于其在产热和能量消耗中的作用而被认为是糖尿病的候选基因。UCP2在几种组织中表达，并在β细胞的胰岛素分泌和脂肪酸代谢的负调节中起作用。UCP3在脂肪酸代谢和能量稳态中起作用，并调节胰岛素敏感性。UCP1、UCP2和UCP3的几个基因多态性被报道与糖尿病相关。本文就UCP1、UCP2和UCP3在糖尿病中的作用作一综述。
Uncoupling proteins (UCPs) are anion carriers expressed in the mitochondrial inner membrane that uncouple oxygen consumption by the respiratory chain from ATP synthesis. The physiological functions of UCPs have long been debated since the new UCPs (UCP2 to 5) were discovered, and the role of UCPs in the pathogeneses of diabetes mellitus is one of the hottest topics. UCPs are thought to be activated by superoxide and then decrease mitochondrial free radicals generation; this may provide a protective effect on diabetes mellitus that is under the oxidative stress conditions. UCP1 is considered to be a candidate gene for diabetes because of its role in thermogenesis and energy expenditure. UCP2 is expressed in several tissues and acts in the negative regulation of insulin secretion by β-cells and in fatty acid metabolism. UCP3 plays a role in fatty acid metabolism and energy homeostasis and modulates insulin sensitivity. Several gene polymorphisms of UCP1, UCP2, and UCP3 were reported to be associated with diabetes. The progress in the role of UCP1, UCP2, and UCP3 on diabetes mellitus is summarized in this review.
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DOI：
10.1093/ecam/nel026
发表时间：
2006-09
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Luo JZ;Luo L
通讯作者：
Luo L
影响因子：
5
作者：
Lee, Hye-Ja;Ryu, Ha-Jung;Oh, Bermseok
通讯作者：
Oh, Bermseok
影响因子：
3.2
作者：
Crispim, Daisy;Fagundes, Nelson J. R.;Canani, Luis H.
通讯作者：
Canani, Luis H.
影响因子：
--
作者：
GELOEN, A;TRAYHURN, P
通讯作者：
TRAYHURN, P
影响因子：
--
作者：
Ma ZA;Zhao Z;Turk J
通讯作者：
Turk J