Dishonorable discharge: the oncogenic roles of cleaved E-cadherin fragments.
Dishonorable discharge: the oncogenic roles of cleaved E-cadherin fragments.
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DOI：
10.1158/0008-5472.can-11-3498
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发表时间：
2012-06-15
期刊：
影响因子：
11.2
通讯作者：
Rajasekaran AK
中科院分区：
文献类型：
--
作者：
David JM;Rajasekaran AK
E-钙粘附素的细胞间黏附丧失是癌症向侵袭性疾病发展过程中发生的一个根本性变化，因为强烈的细胞-细胞相互作用是癌细胞移动的主要障碍。然而，一些侵袭性癌保留了分化上皮细胞的特征，包括E-钙粘附素的表达。新的证据表明，E-钙粘蛋白的蛋白分解产生了促进肿瘤生长、存活和运动的片段，表明E-钙粘附素的裂解将这种肿瘤抑制因子转化为致癌因子。在这篇综述中，我们讨论了切割的E-钙粘素片段作为癌症进展调节器的新角色，并探索了这项研究的翻译和临床意义。
Loss of intercellular adhesion by E-cadherin is a fundamental change that occurs during the progression of cancer to invasive disease as strong cell-cell interaction represents a major barrier to cancer cell mobility. However, some aggressive carcinomas retain characteristics of differentiated epithelial cells including E-cadherin expression. Emerging evidence indicates that proteolysis of E-cadherin generates fragments that promote tumor growth, survival, and motility, suggesting that E-cadherin cleavage converts this tumor suppressor into an oncogenic factor. In this review we discuss the emerging roles of cleaved E-cadherin fragments as modulators of cancer progression and explore the translational and clinical implications of this research.