The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer
The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer
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DOI：
10.21873/anticanres.12605
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发表时间：
2018-06-01
影响因子：
2
通讯作者：
Shimada, Mitsuo
中科院分区：
文献类型：
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作者：
Nishi, Masaaki;Yoshikawa, Kozo;Shimada, Mitsuo
背景/目的：吲哚胺2，3-双加氧酶(IDO)下调T细胞活化，减弱调节性T细胞(Treg)活化，与免疫耐受有关。本研究的目的是阐明IDO在胃癌中的表达意义，并分析IDO、转化生长因子-β和Foxp3在胃癌中的表达之间的关系。患者和方法：本研究共纳入60例III期胃癌根治性胃切除患者。用免疫组织化学方法检测IDO、转化生长因子-β和Foxp3的表达，并用单因素和多因素分析分析各表达水平与多种预后因素的关系。结果：IDO的表达与所检测的任何因素均无正相关。IDO表达与转化生长因子-β表达呈正相关(p
Background/Aim: Indoleamine 2,3-dioxygenase (IDO) down-regulates T cell activation, attenuates regulatory T cell (Treg) activation and is related to immune tolerance. The aim of the study was to clarify the significance of IDO expression and analyze the relationships between the expression of IDO, TGF-beta, and Foxp3 in gastric cancer (GC). Patients and Methods: A total of 60 patients who underwent curative gastrectomy for stage III gastric cancer were included in the study. The expression of IDO, TGF-beta, and Foxp3 was examined by immunohistochemistry and the relationship of each expression level to several prognostic factors was examined using univariate and multivariate analyses. Results: IDO expression was not positively correlated with any of the factors examined. IDO expression was positively correlated with TGF-beta expression (p