HUMAN ADRENOCEPTOR SYSTEM RESPONSE TO THE DEVELOPMENT OF HIGH-ALTITUDE PULMONARY ARTERIAL-HYPERTENSION
HUMAN ADRENOCEPTOR SYSTEM RESPONSE TO THE DEVELOPMENT OF HIGH-ALTITUDE PULMONARY ARTERIAL-HYPERTENSION
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DOI：
10.1016/0022-2828(89)90855-9
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发表时间：
1989-02-01
影响因子：
5
通讯作者：
MIRRAKHIMOV, MM
中科院分区：
文献类型：
--
作者：
ALDASHEV, AA;BORBUGULOV, UM;MIRRAKHIMOV, MM
High-altitude pulmonary arterial hypertension affects people with a long-term residence at altitudes over 2500 m above the sea level and is characterized by elevated pulmonary artery pressure (over 35 15 mmHg). In order to assess the role of β-adrenoreceptors in the development of high-altitude pulmonary arterial hypertension, we studied the β-adrenoreceptor density on mononuclear leukocytes in Kirghiz male natives of Eastern Pamir (3600–4200 m above sea level) with the diagnosis of high-altitude pulmonary arterial hypertension, and in healthy men. It was shown that patients with signs of right ventricular hypertrophy (RVH) of the second and third grade have β-adrenoreceptor density 4.5 times lower than control (2.27±0.22 vs. 9.85±1.28 fmol 10 6 cells). Values of Kd also proved to be lower, by 2.5 times (0.57±0.14 vs. 1.44±0.18 n m). Stimulation of adenylate cyclase by isoproterenol and other β-agonists was lower in patients than in controls (+ 33% and+ 120%, respectively). These results demonstrate that the desensitization of β-adrenoreceptors is present in patients with high-altitude pulmonary arterial hypertension associated with severe right ventricular hypertrophy. Patients with pulmonary arterial hypertension due to mitral stenosis do not have any signs of β-adrenoreceptor desensitization associated with high plasma levels of catecholamines.
