Unirhinal olfactory function in schizophrenia patients and first-degree relatives.
Unirhinal olfactory function in schizophrenia patients and first-degree relatives.
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DOI：
10.1176/jnp.2006.18.3.389
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发表时间：
2006-07
期刊：
影响因子：
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通讯作者：
D. Roalf;B. Turetsky;K. Owzar;Catherine C. Balderston;Sarah C Johnson;C. Brensinger;R. Gur;S. Siegel;P. Moberg
中科院分区：
文献类型：
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作者：
D. Roalf;B. Turetsky;K. Owzar;Catherine C. Balderston;Sarah C Johnson;C. Brensinger;R. Gur;S. Siegel;P. Moberg
先前的研究报告了精神分裂症患者及其家庭成员在气味识别方面的先天缺陷。作者对精神分裂症患者、健康一级亲属和健康对照者进行了单嗅气味识别和检测阈值敏感性试验。患者及其家属均表现出双鼻孔气味识别能力的缺陷。气味检测阈值仅在患者和健康对照者之间存在差异。患者和健康家庭成员的可比气味识别缺陷表明，气味识别措施可能作为敏感的内表型易感性标志物，单嗅嗅觉措施与先天嗅觉措施一样精确，如果不是更精确的话。
Previous studies report birhinal impairments in odor identification in patients with schizophrenia and their family members. The authors employed unirhinal odor identification and detection threshold sensitivity tests in schizophrenia patients, healthy first-degree family members, and healthy comparison subjects. Patients and family members showed deficits in odor identification performance in both nostrils. Odor detection thresholds differed only between patients and healthy comparison subjects. Comparable odor identification deficits in both patients and healthy family members suggest that odor identification measures may serve as a sensitive endophenotypic vulnerability marker and that unirhinal olfactory measures are as precise, if not more so, than birhinal performance measures.