Genetic and environmental contributions to the child behavior checklist Obsessive-Compulsive Scale - A cross-cultural twin study
Genetic and environmental contributions to the child behavior checklist Obsessive-Compulsive Scale - A cross-cultural twin study
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DOI：
10.1001/archpsyc.61.6.608
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发表时间：
2004-06-01
影响因子：
--
通讯作者：
Boomsma, DI
中科院分区：
文献类型：
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作者：
Hudziak, JJ;van Beijsterveldt, CEM;Boomsma, DI
背景：我们已经在其他地方报道了儿童行为检查表（CBCL）中包含的8项强迫症量表（OCS）的发展，以识别符合DSM-IV强迫症标准的儿童。对强迫症的双胞胎研究表明，其表达有重要的遗传成分。目的：利用双胞胎样本的CBCL OCS，确定遗传和环境因素对儿童强迫症行为的相对影响。设计：CBCL数据通过荷兰双胞胎登记处（NTR）和密苏里双胞胎研究（USA/MOTWIN）的双胞胎调查获得。设置：一般社区双胞胎样本。参与者：参与者是来自NTR的4246对7岁的双胞胎，2841对10岁的双胞胎和1562对12岁的双胞胎（他们也在7岁和10岁时参与了研究），以及来自美国/MOTWIN的1461对混合年龄双胞胎（平均年龄约9岁）。主要结果测量：模型拟合检验遗传和环境影响、性别差异和兄弟姐妹相互作用/比较对比对CBCL OCS的影响。结果：在每种情况下，最佳拟合模型是一个表明显著的加性遗传影响（范围，45%-58%；95%置信区间[CI]， 45%-61%）和独特的环境影响（范围，42%-55%;95% CI, 39%-55%）的模型，在12岁的NTR样本中具有共同的环境影响（16%）。在混合年龄USA/MOTWIN模型中可以看到性别差异，但在NTR样本中没有。没有证据表明优势、兄弟姐妹互动或对比效应。这些数据在不同的年龄和文化中相对一致。结论：在较年轻的样本中，CBCL OCS受遗传因素（约55%）和独特环境因素（约45%）的影响，而常见的环境影响仅在12岁时发生。这些影响不随性别或兄弟姐妹互动/对比效应的差异而变化。我们的数据显示，基因对强迫症行为的影响更大，并没有显示出性别间的基因差异。
Context: We have reported elsewhere on the development of an 8-item Obsessive-Compulsive Scale (OCS) contained in the Child Behavior Checklist (CBCL) to identify children who meet criteria for DSM-IV obsessive-compulsive disorder. Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression.Objective: To determine the relative contributions of genetic and environmental influences on childhood obsessive-compulsive behavior using the CBCL OCS in twin samples.Design: The CBCL data were received by survey of twins in the Netherlands Twin Registry (NTR) and the Missouri Twin Study (USA/MOTWIN).Setting: General community twin samples.Participants: Participants were 4246 twin pairs aged 7 years, 2841 aged 10 years, and 1562 aged 12 years (who also participated in the study at 7 and 10 years of age) from the NTR and 1461 mixed-age twin pairs (average age, approximately 9 years) from the USA/MOTWIN.Main Outcome Measures: Model fitting to test for genetic and environmental influences, sex differences, and sibling interaction/rater contrast effects on the CBCL OCS.Results: In each case, the best-fitting model was one that indicated significant additive genetic influences (range, 45%-58%; 95% confidence interval [CI], 45%-61%), and unique environmental influences (range, 42%-55%; 95% CI, 39%-55%), with shared environmental influences in the NTR sample aged 12 years (16%). Sex differences were seen in the mixed-age USA/MOTWIN model, but not in the NTR samples. No evidence of dominance, sibling interaction, or rater-contrast effects was seen. These data were relatively consistent across age and cultures.Conclusions: The CBCL OCS is influenced by genetic factors (approximately 55%) and unique environmental factors (approximately 45%) in the younger sample, with common environmental influences only at 12 years of age. These effects do not vary with differences in sex or sibling interaction/rater contrast effects. Our data reveal higher genetic influences for obsessive-compulsive behavior and do not demonstrate genetic differences across sex.