An inhibitory effect of psychoactive drugs on a human neuroblastoma cell line.
An inhibitory effect of psychoactive drugs on a human neuroblastoma cell line.
复制标题
精神活性药物对人神经母细胞瘤细胞系的抑制作用。
DOI：
10.1016/0006-3223(94)91145-2
复制
发表时间：
1994
影响因子：
10.6
通讯作者：
Nimgaonkar,VL
中科院分区：
文献类型：
--
作者：
Silver,MA;Yang,ZW;Ganguli,R;Nimgaonkar,VL
检查抗精神病药物对培养的人神经母细胞瘤细胞的影响。在存在或不存在各种浓度的氟哌啶醇 (HL)、顺式氟哌噻吨 (CFL)、反式氟哌噻吨 (TFL)、氟奋乃静 (FL)、去甲基丙咪嗪和 N-甲基-D-天冬氨酸 (NMDA) 的情况下，细胞生长 4 天。通过测量每个试验孔中活细胞的数量来确定药物效果。 HL、CFL、TFL 和 FL 以剂量依赖性方式减少活细胞。 FL 最为有效，其次是 TFL、CFL 和 HL。（PsycINFO 数据库记录 (c) 2018 APA，保留所有权利）
Examined the effects of antipsychotic drugs on cultured human neuroblastoma cells. Cells were grown for 4 days in the presence or absence of various concentrations of haloperidol (HL), cis-flupenthixol (CFL), trans-flupenthixol (TFL), fluphenazine (FL), desmethylimipramine, and N-methyl-D-aspartate (NMDA). Drug effects were determined by measuring the number of viable cells in each trial well. HL, CFL, TFL, and FL reduced viable cells in a dose-dependent manner. FL was the most potent, followed by TFL, CFL, and HL.(PsycINFO Database Record (c) 2018 APA, all rights reserved)