Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases.
Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases.
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DOI：
10.1002/ags3.12578
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发表时间：
2022-11
影响因子：
2.7
通讯作者：
Ikegami, Toru
中科院分区：
文献类型：
--
作者：
Tanji, Yoshiaki;Furukawa, Kenei;Haruki, Koichiro;Taniai, Tomohiko;Onda, Shinji;Tsunematsu, Masashi;Shirai, Yoshihiro;Yanagaki, Mitsuru;Igarashi, Yosuke;Ikegami, Toru
本研究旨在研究结直肠癌肝转移（CRLM）患者肝切除术后术前恶病质指数（CXI）与长期结局之间的关系。回顾性分析了118例因CRLM行肝切除术的患者。研究了CXI与肝切除术后患者长期结局之间的关系。根据术前骨骼肌指数、血清白蛋白水平和嗜中性粒细胞-淋巴细胞比率计算CXI。多变量分析显示，肝外病变（风险比[HR] 2.86，95%置信区间[CI] 1.48-5.53，P <0.01）和高CXI（HR 0.44，95% CI 0.20-0.98，P = 0.04）是无病生存期的独立和重要预测因素。此外，肝外病变（HR 2.32，95% CI 1.03-5.22，P = 0.04）、高CXI（HR 0.17，95% CI 0.05-0.57，P <0.01）和可治愈性R 1或2（HR 3.29，95% CI 1.23-8.78，P = 0.02）是总生存期的独立和重要预测因素。CXI是CRLM患者肝切除术后无病生存期和总生存期的有用预后因素。我们研究了结直肠肝转移（CRLM）患者术前CXI与肝切除术后长期结局之间的关系，这是第一份报告表明CXI是CRLM患者肝切除术后有用的预后决定因素。#10;与低CXI患者组相比，高CXI患者组的DFS和OS主要延长。
The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long‐term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection. In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long‐term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil–lymphocyte ratio. The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48–5.53, P < .01) and high CXI (HR 0.44, 95% CI 0.20–0.98, P = .04) were independent and significant predictors of disease‐free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03–5.22, P = .04), high CXI (HR 0.17, 95% CI 0.05–0.57, P < .01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23–8.78, P = .02) were independent and significant predictors of overall survival. CXI is a useful prognostic factor for disease‐free survival and overall survival after hepatic resection in CRLM patients. We investigate the relationship between preoperative CXI and long‐term outcome after hepatectomy in patients with colorectal liver metastases (CRLM), and this is the first report to show that CXI is a useful prognostic determinant after hepatectomy in patients with CRLM. #10;DFS and OS were predominantly prolonged in the group of patients with high CXI compared to the group of patients with low CXI.
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DOI：
10.1097/spc.0000000000000091
发表时间：
2014-12
影响因子：
2.1
作者：
Narsale AA;Carson JA
通讯作者：
Carson JA
影响因子：
2.4
作者：
Katanoda, Kota;Kamo, Ken-Ichi;Nishimoto, Hiroshi
通讯作者：
Nishimoto, Hiroshi
影响因子：
4.6
作者：
Liu, Yueh-Wei;Lu, Chien-Chang;Hung, Chao-Hung
通讯作者：
Hung, Chao-Hung
影响因子：
3
作者：
MIYAGAWA, S;MAKUUCHI, M;KAKAZU, T
通讯作者：
KAKAZU, T
影响因子：
3.4
作者：
Neal, Christopher P.;Cairns, Vaux;Dennison, Ashley R.
通讯作者：
Dennison, Ashley R.