The influence of leptin on early life programming of obesity.
The influence of leptin on early life programming of obesity.
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DOI：
10.1016/j.tibtech.2008.06.004
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发表时间：
2008-10
影响因子：
17.3
通讯作者：
C. Stocker;M. Cawthorne
中科院分区：
文献类型：
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作者：
C. Stocker;M. Cawthorne
流行病学证据和实验模型表明，胎儿和出生后早期生长模式与成人代谢疾病风险增加之间存在直接关系。产妇健康和营养是影响婴儿生长的关键决定因素，但这种关系背后的确切分子机制尚不清楚，尽管很明显，当这些影响很重要时，存在关键的时间窗口。动物模型显示出与人类群体的机制相似之处，并强调早期环境代表了预防肥胖和代谢疾病的治疗窗口。发育编程可以逆转的观察结果已经在研究中得到证实，其中母体和新生儿瘦素治疗都可以防止不良代谢表型的诱导。考虑到口服给药的肽被新生儿完整吸收，作为减少或逆转肥胖和2型糖尿病流行的手段，以滴剂或牛奶形式提供补充性瘦素的前景值得认真考虑。
Epidemiological evidence together with experimental models shows a direct relationship between fetal and early postnatal growth patterns and an increased risk of adult metabolic disease. Maternal health and nutrition are key determinants in influencing infant growth but the precise molecular mechanisms underlying this relationship are unclear, although it is evident that there are critical time windows when these effects are important. Animal models show mechanistic parallels with human populations and highlight that the early environment represents a therapeutic window for protection from obesity and metabolic disease. The observation that developmental programming can be reversed has been demonstrated in studies in which both maternal and neonatal leptin treatment prevents the induction of the adverse metabolic phenotype. Given that orally administered peptides are absorbed intact by the new born, the prospect of providing supplemental leptin either as drops or in milk deserves serious consideration as a means of reducing or reversing the obesity and type 2 diabetes epidemic.