Probing the Complexities of Astrocyte Calcium Signaling.
Probing the Complexities of Astrocyte Calcium Signaling.
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探测星形胶质细胞钙信号的复杂性。
DOI：
10.1016/j.tcb.2016.01.003
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发表时间：
2016-04
影响因子：
19
通讯作者：
Khakh BS
中科院分区：
文献类型：
--
作者：
Shigetomi E;Patel S;Khakh BS
星形胶质细胞是一种丰富的胶质细胞，分布在整个中枢神经系统中，介导神经元、血管和其他胶质细胞的成熟功能。这些无处不在的细胞显示细胞内Ca2+信号，这已经被深入研究了25年。最近，使用改进的方法已经发现了星形胶质细胞Ca2+信号的全貌和基础Ca2+水平的可变景观。体内研究已经开始揭示星形胶质细胞显示行为相关的Ca2+信号的设置。小鼠研究强调了星形胶质细胞Ca2+信号如何在不同的神经退行性疾病中改变。在过去的几年里，在方法学进步的推动下，人们重新燃起了对星形胶质细胞Ca2+信号对大脑功能和功能障碍的兴趣。
Astrocytes are abundant glial cells that tile the entire central nervous system and mediate well established functions for neurons, blood vessels and other glia. These ubiquitous cells display intracellular Ca2+ signals, which have been intensely studied for 25 years. Recently, the use of improved methods has unearthed the panoply of astrocyte Ca2+ signals and a variable landscape of basal Ca2+ levels. In vivo studies have started to reveal the settings under which astrocytes display behaviorally relevant Ca2+ signaling. Studies in mice have emphasized how astrocyte Ca2+ signaling is altered in distinct neurodegenerative diseases. Progress in the last few years, fueled by methodological advances, has thus reignited interest in astrocyte Ca2+ signaling for brain function and dysfunction.