Hypovascular hepatic nodule showing hypointensity in the hepatobiliary phase of gadoxetic acid-enhanced MRI in patients with chronic liver disease: Prediction of malignant transformation
Hypovascular hepatic nodule showing hypointensity in the hepatobiliary phase of gadoxetic acid-enhanced MRI in patients with chronic liver disease: Prediction of malignant transformation
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DOI：
10.1016/j.ejrad.2012.05.008
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发表时间：
2012-11-01
影响因子：
3.3
通讯作者：
Honda, Hiroshi
中科院分区：
文献类型：
--
作者：
Takayama, Yukihisa;Nishie, Akihiro;Honda, Hiroshi
目的：探讨肝胆期低血管低信号结节恶变的预测因素。材料与方法：回顾分析24例103个肝胆系疾病患者的动态增强CT(DCE-CT)和增强MRI的临床和影像资料。随访结果分析后，将HHN分为3组：(1)结节伴增大和(或)血管化及其他结节，(2)仅增大及其他结节，(3)仅有血管化结节及其他结节。在随访期内增大和/或血管形成被定义为HHN的恶变。结果：多因素分析显示，首次增强扫描结节直径大于或等于9 mm是HHN增大和/或血管化的显著预测因素(P<；0.05)。另一方面，初始DCE-CT延迟相成像的低密度是HHN增大或血管化的重要预测因素(P<；0.05)。结论：初始DCE-CT延迟相成像的低密度和初始DCE-CT延迟相成像的低密度有助于预测有肝细胞癌风险的患者HHN的预后。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To investigate the predictive factors of malignant transformation of hypovascular hepatic nodule showing hypointensity in the hepatobiliary phase images of gadoxetic acid-enhanced MRI (HHN).Materials and Methods: The clinical data and imaging findings of dynamic contrast-enhanced computed tomography (DCE-CT) and gadoxetic acid-enhanced MRI for a total of 103 HHNs in 24 patients with chronic liver disease were retrospectively investigated. After the results of follow-up examinations were investigated, HHNs were categorized into the three groups for each comparison: (1) nodules with enlargement and/or vascularization and others, (2) nodules with only enlargement and others, (3) nodules with only vascularization and others. Enlargement and/or vascularization during the follow-up period were defined as malignant transformation of HHN. The frequency of each clinical datum and imaging finding in each group was compared to identify the predictive factors for malignant transformation in HHN.Results: Multivariate analysis showed that a nodule size of 9 mm or more on the initial gadoxetic acid-enhanced MRI was a significant predictive factor for the enlargement and/or vascularization of HHN (P < 0.05). On the other hand, the hypoattenuation on the delayed phase imaging of the initial DCE-CT was a significant predictive factor for the enlargement or vascularization of HHN (P < 0.05).Conclusion: A nodule size of 9 mm or more on the initial gadoxetic acid-enhanced MRI and hypoattenuation on the delayed phase imaging of initial DCE-CT would be helpful for predicting the outcome of HHN in patients with a risk of hepatocellular carcinoma. (C) 2012 Elsevier Ireland Ltd. All rights reserved.