Estrous cycle influence on individual differences in the response to novelty and cocaine in female rats.
Estrous cycle influence on individual differences in the response to novelty and cocaine in female rats.
复制标题
发情周期对雌性大鼠对新奇事物和可卡因反应个体差异的影响。
DOI：
10.1016/j.bbr.2005.01.004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Thomas,MaryL
中科院分区：
文献类型：
--
作者：
Sell,StacyL;Dillon,AshleeM;Cunningham,KathrynA;Thomas,MaryL
在大鼠中，可以通过个体对新环境的运动反应来预测个体对自我给药滥用药物的脆弱性差异。这种现象已在雄性大鼠中得到很好的描述，但关于雌性大鼠和影响活动水平的发情周期激素变化的额外并发症的信息很少。本研究旨在探讨个体对暴露于新环境的反应性、发情周期和对可卡因的反应性之间的关系。在暴露于新环境后，测量未处理雌性大鼠的自发活动，然后测定动情周期阶段和循环雌二醇水平。根据运动反应，将大鼠确定为高反应（HR; 15%最活跃）或低反应（LR; 15%最不活跃）大鼠。高血压大鼠对可卡因的反应比低血压大鼠更活跃。这些数据结合发情期的评价表明，发情周期与个体表型特征相互作用，以改变雌性动物对可卡因的敏感性。
In rats, individual differences in vulnerability to self-administration of drugs of abuse can be predicted by individual locomotor responses to a novel environment. This phenomenon has been well described for male rats, however very little information is available with regard to female rats and the added complication of estrous cycle hormone changes influencing activity levels. This study was designed to explore the relationship between individual responsiveness to exposure to a novel environment, the estrous cycle, and the response to cocaine in intact, cycling female rats. Locomotor activity of naïve female rats was measured upon exposure to a novel environment followed by determination of estrous cycle stage and level of circulating estradiol. Rats were identified as high-responder (HR; 15% most active) or low-responder (LR; 15% least active) rats based on the locomotor response. Hyperactivity in response to cocaine was greater in HR than in LR rats. These data in combination with evaluation of the stage of estrous suggest that the estrous cycle interacts with individual phenotypic characteristics to modify the sensitivity to cocaine in female animals.