REPEATED PARTIAL SLEEP-DEPRIVATION PROGRESSIVELY CHANGES THE EEG DURING SLEEP AND WAKEFULNESS
REPEATED PARTIAL SLEEP-DEPRIVATION PROGRESSIVELY CHANGES THE EEG DURING SLEEP AND WAKEFULNESS
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DOI：
10.1093/sleep/16.2.100
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发表时间：
1993-02-01
期刊：
影响因子：
5.6
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
--
作者：
BRUNNER, DP;DIJK, DJ;BORBELY, AA
研究人员在九名健康的年轻受试者中研究了重复部分睡眠剥夺对睡眠阶段以及睡眠和清醒期间脑电图（EEG）功率谱的影响。三个 8 小时的基线夜晚（2300-0700 小时）之后是四个 4 小时睡眠的夜晚（2300-0300 小时）和三个 8 小时的恢复夜晚（2300-0700 小时）。睡眠限制减少了第一阶段和第二阶段的睡眠以及快速眼动 (REM) 睡眠，但慢波睡眠基本上不受影响。在前两个恢复之夜，总睡眠时间和快速眼动睡眠时间均增加，睡眠潜伏期缩短。慢波睡眠仅在第一个恢复晚上有所增加。根据睡眠调节双过程模型的预测，非快速眼动 (NREM) 睡眠中的慢波活动（SWA；0.75-4.5 Hz 范围内的频谱功率密度）在睡眠限制后的第一个晚上增加了约 20%，在随后的 3 个晚上保持在这个水平，并在第一个恢复晚上后立即下降。与这些直接变化相反，在较高频率的脑电图活动中可以看到进行性和更持久的变化。因此，在睡眠限制期间，上δ带的活动往往逐渐增加，而在最初增加后，θ-α带的活动向相反的方向变化。快速眼动睡眠和清醒状态的脑电图谱也出现了渐进性的变化。由于这些变化的时间进程与快速眼动睡眠的累积缺陷平行，因此它们可能代表快速眼动睡眠压力的相关性。
The effect of repeated partial sleep deprivation on sleep stages and electroencephalogram (EEG) power spectra during sleep and wakefulness was investigated in nine healthy young subjects. Three baseline nights of 8 hours (2300-0700 hours) were followed by four nights with 4 hours of sleep (2300-0300 hours) and three recovery nights of 8 hours (2300-0700 hours). Sleep restriction curtailed sleep stages 1 and 2 as well as rapid eye movement (REM) sleep, but left slow wave sleep largely unaffected. In the first two recovery nights, total sleep time and REM sleep were enhanced, and sleep latency was shortened. Slow wave sleep was increased only in the first recovery night. In accordance with the prediction of the two-process model of sleep regulation, slow wave activity (SWA; spectral power density in the 0.75-4.5-Hz range) in nonrapid eye movement (NREM) sleep increased by approximately 20% in the first night following sleep restriction, remained at this level in the subsequent 3 nights and decreased immediately after the first recovery night. In contrast to these immediate changes, progressive and more persistent changes were seen in the EEG activity of higher frequencies. Thus, activity in the upper delta band tended to gradually increase from night to night during the sleep restriction period, whereas after an initial increase, activity in the theta-alpha band changed in the opposite direction. The progressive changes were also present in the EEG spectra of REM sleep and wakefulness. Because the time course of these changes paralleled the cumulative deficit in REM sleep, they may represent a correlate of REM sleep pressure.