Lack of effect of transdermal estrogen on the growth hormone-insulin-like growth factor axis.
Lack of effect of transdermal estrogen on the growth hormone-insulin-like growth factor axis.
复制标题
透皮雌激素对生长激素-胰岛素样生长因子轴缺乏作用。
DOI：
10.1055/s-2007-1000814
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Ceda,GP
中科院分区：
文献类型：
--
作者：
Dall'Aglio,E;Valenti,G;Hoffman,AR;Zuccarelli,A;Passeri,M;Ceda,GP
生长激素（GH）释放激素（GHRH）-GH-胰岛素样生长因子（IGF）轴的活性随着年龄的增长而下降，这种现象被称为体细胞死亡（somatopause）（霍夫曼，Pyka，Lieberman，Ceda and Marcus 1993）。雌激素在女性这种下降中的作用最近得到了评估。在年轻人中，女性的GH水平高于男性，血清雌激素与GH水平呈正相关。雌激素和孕激素都能增强生长抑素抑制剂吡啶斯的明对GH的反应（O 'Keane and Dinen 1992）。绝经开始后，血浆IGF-I水平立即下降（Romagnoli、Minisola、Rovevale、Scarda、罗索、Scarnecchia、Pacitti和Mazzuoli 1993），平均24小时GH和血清IGF-I水平低于绝经前对照组。口服炔雌醇增加血清GH，但降低IGF-I水平（Dawson-Hughes、Stern、Goldman和Reichlin 1986），表明GH在肝脏的作用受阻。我们在服用结合雌激素的患者中获得了类似的IGF-I结果
The activity of the growth hormone (GH) releasing hormone (GHRH)-GH-insulin-like growth factor (IGF) axis declines with aging, a phenomenon which has been termed the somatopause (Hoffman, Pyka, Lieberman, Ceda and Marcus 1993). The role of estrogen in this decline in women has recently been evaluated. In young adults, GH levels are higher in women than in men, and there is a positive correlation between serum estrogen and GH levels. Both estrogen and progesterone enhance the GH response to the somatostatin-inhibitor, pyridostigmine (O'Keane and Dinen 1992). Plasma IGF-I levels fall immediately after the onset of the menopause (Romagnoli, Minisola, Carnevale, Scarda, Rosso, Scarnecchia, Pacitti and Mazzuoli1993) and mean 24 hour GH and serum IGF-I levels are lower than in premenopausal controls. Oral ethinyl-estradiol increased serum GH, but lowered IGF-I levels (Dawson-Hughes, Stern, Goldman and Reichlin 1986), suggesting a block in GH action at the liver. We have obtained similar IGF-I results in patients taking conjugated estrogens