Magnetic iron oxide nanoworms for tumor targeting and imaging
Magnetic iron oxide nanoworms for tumor targeting and imaging
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DOI：
10.1002/adma.200800004
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发表时间：
2008-05-05
影响因子：
29.4
通讯作者：
Sailor, Michael J.
中科院分区：
文献类型：
--
作者：
Park, Ji-Ho;von Maltzahn, Geoffrey;Sailor, Michael J.
合成、体外及体内研究
这些颗粒由葡聚糖涂层内的氧化铁（IO）核呈链状聚集而成。当与肿瘤靶向肽结合时，相较于球形纳米颗粒，它们在体外与基于肿瘤的靶点能更有效地相互作用。与非靶向球形氧化铁纳米颗粒相比，非靶向纳米线（NW）在体内显示出相似的循环时间，且在小鼠异种移植肿瘤中的被动聚集增强。
The synthesis, in vitro, and in vivo The particles consist of a chainlike aggregation of iron oxide (IO) cores in a dextran coating. When conjugated with a tumor-targeting peptide, they interact more effectively with a tumor-based target in vitro relative to spherical nanoparticles. Untargeted NW display similar in vivo circulation times and enhanced passive accumulation in mouse xenograft tumors relative to untargeted spherical IO nanoparticles.