Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology.
Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology.
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DOI：
10.1186/1471-2180-9-s1-s2
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发表时间：
2009-02-19
期刊：
影响因子：
4.2
通讯作者：
Setubal JC
中科院分区：
文献类型：
--
作者：
Tseng TT;Tyler BM;Setubal JC
蛋白质分泌在调节细菌与其环境的相互作用中起着核心作用。当共生细菌（无论是致病菌、共生菌还是互利菌）与较大的宿主生物相互作用时，情况尤其如此。在革兰氏阴性菌的情况下，分泌物需要穿过外膜以及内膜的易位，并且已经为此目的而精心设计了多种分子机器。许多分泌的蛋白质注定要进入宿主细胞（效应物和毒素），因此几种分泌系统也包括将蛋白质转运穿过宿主质膜的装置。植物相关微生物基因本体论（PAMGO）联盟一直在开发标准化术语，用于描述在微生物与植物和动物宿主的相互作用中发挥重要作用的生物过程和细胞组分，包括细菌分泌过程。在这里，我们调查已知的细菌分泌系统调节与宿主生物体的相互作用，并描述基因本体论术语用于描述这些系统的组件和功能，并捕捉不同系统之间的相似性。
Protein secretion plays a central role in modulating the interactions of bacteria with their environments. This is particularly the case when symbiotic bacteria (whether pathogenic, commensal or mutualistic) are interacting with larger host organisms. In the case of Gram-negative bacteria, secretion requires translocation across the outer as well as the inner membrane, and a diversity of molecular machines have been elaborated for this purpose. A number of secreted proteins are destined to enter the host cell (effectors and toxins), and thus several secretion systems include apparatus to translocate proteins across the plasma membrane of the host also. The Plant-Associated Microbe Gene Ontology (PAMGO) Consortium has been developing standardized terms for describing biological processes and cellular components that play important roles in the interactions of microbes with plant and animal hosts, including the processes of bacterial secretion. Here we survey bacterial secretion systems known to modulate interactions with host organisms and describe Gene Ontology terms useful for describing the components and functions of these systems, and for capturing the similarities among the diverse systems.