THE PROVOCATION OF CORONARY ARTERIAL SPASM IN PATIENTS WITH RECENT TRANSMURAL MYOCARDIAL-INFARCTION
THE PROVOCATION OF CORONARY ARTERIAL SPASM IN PATIENTS WITH RECENT TRANSMURAL MYOCARDIAL-INFARCTION
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DOI：
10.1093/oxfordjournals.eurheartj.a061518
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发表时间：
1983-01-01
影响因子：
39.3
通讯作者：
CHAHINE, RA
中科院分区：
文献类型：
--
作者：
BERTRAND, ME;LABLANCHE, JM;CHAHINE, RA
对131例近期（<6周）发生透壁性心肌梗死的患者（124例男性和7例女性）进行了冠状动脉痉挛激发试验。在梗死发生后27±9天进行冠状动脉造影。使用0.4 mg麦角新碱的单次IV推注进行激发试验。3、5min后复查主动脉压、心电图及两支冠状动脉造影。在27例（21%）患者中观察到诱发性痉挛。13例（48%）冠状动脉痉挛发生在可能导致心肌梗死的血管中，14例（52%）冠状动脉痉挛发生在与梗死区域无关的血管中。因此，本研究证实了近期透壁性心肌梗死患者冠状动脉树的高度反应性，表明痉挛在梗死过程中可能发挥作用，并为随后的复发性缺血事件提供了一些解释。
Provocative tests for coronary spasm were performed in a group of 131 patients (124 men and 7 women) with recent (<6 weeks) transmural myocardial infarction. Coronary arteriography was performed 27±9 days after the onset of the infarction. The provocative test was performed using a single IV bolus of 0.4 mg of ergometrine. Aortic pressure, ECG and arteriograms of the two coronary vessels were repeated 3 and 5 min later. Provoked spasm was observed in 27 (21%) of the patients. In 13 (48%) the coronary spasm occurred in a vessel presumed to be responsible for the myocardial infarction, while it was observed in coronary artery unrelated to the area of the infarct in 14 (52% of the cases with spasm). Thus, this study demonstrates a high degree of reactivity of the coronary tree of patients with recent transmural myocardial infarction suggesting the likelihood of a role for spasm in the infarction process and offering some explanation for subsequent recurrent ischemic events.