Increased plasma levels of IL-6 and IL-8 are associated with surgical site infection after pancreaticoduodenectomy
Increased plasma levels of IL-6 and IL-8 are associated with surgical site infection after pancreaticoduodenectomy
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DOI：
10.1097/01.mpa.0000202959.63977.5c
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发表时间：
2006-03-01
期刊：
影响因子：
2.9
通讯作者：
Miyazaki, Masaru
中科院分区：
文献类型：
--
作者：
Kimura, Fumio;Shimizu, Hiroaki;Miyazaki, Masaru
目的：细胞因子和趋化因子可能调节术后免疫反应。方法：对60例胰腺十二指肠切除术患者围手术期血浆IL-6、IL-10、IL-8、巨噬细胞趋化蛋白1、热休克蛋白70、淀粉酶水平及腹腔液淀粉酶水平进行检测。结果：60例患者中有27例发生手术部位感染(SSI)，其中腹膜感染14例，腹部脓肿14例，胰腺漏6例。术后血浆IL-6、IL-8和AGE巨噬细胞趋化蛋白1水平及腹膜淀粉酶水平。结果：60例患者中有27例发生手术部位感染，其中腹膜感染14例，胰腺漏6例。有SSI的患者显著高于无SSI的患者(P<；0.05)。多因素Logistic回归分析显示，病理诊断为非胰腺癌、高胰液流量、IL-6和IL-8水平升高与SSI独立相关(P<；0.05)。结论：IL-6和IL-8除与胰腺外分泌功能有关外，还与术后SSI的发生有关，包括胰腺十二指肠切除术后的胰漏。
Objectives: Cytokines and chemokines potentially modulate postoperative immune response. Association of circulating cytokines and chemokines with postoperative infectious complications after pancreaticoduodenectomy was evaluated.Methods: Plasma concentrations of interleukin (IL) 6, IL-10, IL-8, macrophage chemoattractant protein 1, heat shock protein 70, and amylase, as well as amylase levels in peritoneal exudative fluid, were measured perioperatively in 60 consecutive patients who underwent pancreaticoduodenectomy.Results: Of the 60 patients, 27 patients had surgical site infection (SSI), including peritoneal infection in all, intra-abdominal abscess in 14, and radiologically visualized pancreatic leakage in 6. Postoperative plasma levels of IL-6, IL-8, and macrophage chemoattractant protein 1, as well as peritoneal amylase levels, were significantly higher in patients with SSI than in those without SSI (P < 0.05). Nonpancreatic cancer as a histopathologic diagnosis, high pancreatic juice flow, and increased levels of IL-6 and IL-8 were independently associated with SSI (P < 0.05) in multiple logistic regression analysis. Plasma levels of IL-6 and IL-10 among patients with SSI were significantly higher in those with pancreatic leakage than in those without leakage.Conclusions: These results suggest that, in addition to pancreatic exocrine function, IL-6 and IL-8 are associated with postoperative SSI, including pancreatic leakage after pancreaticoduodenectomy.