Oral manifestations of patients with Marfan syndrome: A case-control study
Oral manifestations of patients with Marfan syndrome: A case-control study
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DOI：
10.1067/moe.2002.121430
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发表时间：
2002-05-01
期刊：
影响因子：
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通讯作者：
De Paepe, A
中科院分区：
文献类型：
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作者：
De Coster, PJA;Martens, LCM;De Paepe, A
目标。本研究的目的是对马凡氏综合征患者的口腔异常进行完整的分析。研究设计。研究了23例马凡氏综合征患者和69名健康对照者。对受试者进行龋齿和牙周病变以及牙釉质和牙本质结构缺陷的筛查。数据分析采用检验、卡方检验和回归模型。0 ~ 17岁的患者患龋齿的风险显著。局部发育不全的牙釉质斑在马凡氏综合征中更为常见，可能与乳牙列的龋史有关。牙根畸形、牙髓形状异常和牙髓内含物是马凡氏综合征患者的常见症状。研究组牙石及牙龈指标均明显高于对照组。本研究显示早期诊断口腔异常及及时治疗马凡氏综合征的重要性。提出了一系列的治疗指南，以纳入治疗策略。
Objective. The purpose of this study was to conduct a complete analysis of the oral abnormalities of patients with Marfan syndrome.Study design. Twenty three patients with Marfan syndrome and 69 healthy controls were studied. The subjects were screened for cariologic and periodontal alterations, as well as structural defects of enamel and dentin. Data analysis was performed by using the test, the chi-square test, and regression models.Results. Patients aged 0 to 17 years were significantly at risk for caries. Local hypoplastic enamel spots were more frequent in Marfan syndrome and could be related to caries history of the deciduous dentition. Root deformity, abnormal pulp shape, and pulpal inclusions were a frequent finding in patients with Marfan syndrome. Calculus and gingival indices were significantly higher in the study group as well.Conclusions. This study shows the importance of early diagnosis of oral anomalies and timely treatment of dental problems in Marfan syndrome. A series of therapeutic guidelines to be integrated in treatment strategies is proposed.