Intergenerational Effects of Early Life Nutrition: Maternal Leg Length Predicts Offspring Placental Weight and Birth Weight Among Women in Rural Luzon, Philippines
Intergenerational Effects of Early Life Nutrition: Maternal Leg Length Predicts Offspring Placental Weight and Birth Weight Among Women in Rural Luzon, Philippines
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DOI：
10.1002/ajhb.22579
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发表时间：
2014-09-01
影响因子：
2.9
通讯作者：
Kuzawa, Christopher W.
中科院分区：
文献类型：
--
作者：
Chung, Green C.;Kuzawa, Christopher W.
目的：腿长是身高中对早期营养最敏感的组成部分；因此，它为回顾性评估妇女婴儿期和幼儿期营养与后代出生体重（BW）之间的关系提供了机会。在这里，我们探讨了菲律宾农村社区母亲腿长与后代体重之间的关系，同时也研究了胎盘大小作为一种途径的潜在作用。方法：对菲律宾安提波罗市一家分娩诊所的孕妇（年龄17-42岁）（n=80）进行人体测量和问卷调查。分娩时采集子代b和胎盘重量。结果：母亲腿长与婴儿体重呈正相关，而躯干长度与婴儿体重呈正相关。在调整胎龄和母亲体重指数（BMI）后，这种关系得到加强。进一步调整胎盘重量会减弱腿长与体重之间的关系，而胎盘重量与母体躯干长度无关。调整胎盘重量后，母体体重指数与体重之间的关系也减弱。结论：母体腿长是该样本中最能预测子代胎盘体重和体重的身高组成部分。这些发现表明，这一代胎儿的营养和生长在一定程度上受到母亲自己早期生活生长条件的影响。我们的研究结果进一步证明，胎儿营养与母亲过去的营养经历有关，同时也表明，在婴儿期和幼儿期确保良好的生长条件不仅有利于这一代，也有利于未来的后代。点。j .的嗡嗡声。生物学报，26(6):652-659,2014。(C) 2014 Wiley期刊公司
Objectives: Leg length is the component of stature most sensitive to early life nutrition; as such, it provides an opportunity to retrospectively evaluate the relationship between a woman's infancy and early childhood nutrition and offspring birth weight (BW). Here we explore the relationship between maternal leg length and offspring BW in a rural Philippine community, while also investigating the potential role of placental size as a pathway.Methods: Anthropometric and questionnaire data were obtained among pregnant women (ages 17-42 years) at a birthing clinic in Antipolo City, Philippines (n=80). Offspring BWand placental weight were collected upon delivery.Results: Maternal leg length, but not trunk length, was a positive predictor of infant BW. This relationship was strengthened after adjusting for gestational age and maternal body mass index (BMI). Further adjustment for placental weight attenuated the relationship between leg length and BW, while placental weight was unrelated to maternal trunk length. The relationship between maternal BMI and BW was also attenuated after adjustment for placental weight.Conclusion: Maternal leg length is the component of stature that most strongly predicts offspring placental weight and BW in this sample. These findings suggest that fetal nutrition and growth in the present generation are influenced, in part, by the mother's own early life growth conditions. Our results add to evidence that fetal nutrition tracks the mother's past nutritional experiences, while also suggesting that ensuring favorable growth conditions during infancy and early childhood may benefit not only the present generation, but future offspring. Am. J. Hum. Biol. 26: 652-659, 2014. (C) 2014 Wiley Periodicals, Inc.