Prenatal phthalate exposure and fetal penile length and width.
Prenatal phthalate exposure and fetal penile length and width.
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产前邻苯二甲酸盐暴露与胎儿阴茎长度和宽度。
DOI：
10.1038/s41390-023-02939-x
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发表时间：
2023
影响因子：
3.6
通讯作者：
Mehta-Lee,ShilpiS
中科院分区：
文献类型：
--
作者：
Salvi,NicoleB;Ghassabian,Akhgar;Brubaker,SaraG;Liu,Hongxiu;Kahn,LindaG;Trasande,Leonardo;Mehta-Lee,ShilpiS
邻苯二甲酸盐是一种具有抗雄激素特性的内分泌干扰化学物质，研究报告了产前邻苯二甲酸盐暴露与婴儿生殖器之间的关系。本研究调查了产前邻苯二甲酸盐暴露增加是否与胎儿阴茎测量减少有关。方法数据来自纽约大学儿童健康与环境研究（2016-2019）。在妊娠<18周时，对16种邻苯二甲酸酯代谢物的母体尿液浓度进行了量化，作为胎儿暴露的代表（n= 334名男性妊娠）。我们在妊娠18-24周（n= 173个胎儿）使用超声波回顾性测量了阴茎的长度和宽度。结果西班牙裔妇女占57.2%，非西班牙裔白人占31.8%，亚裔占6.4%，非西班牙裔黑人占2.3%，多种族妇女占2.3%。产妇平均年龄32岁（标准差[SD] = 5.7）。平均阴茎长7.13 mm (SD = 1.47)，宽6.16 mm （SD = 0.87）。母体邻苯二甲酸单乙酯水平与胎儿阴茎长度呈反比关系，邻苯二甲酸单（7-羧基-正庚基）酯水平与阴茎宽度呈反比关系，尽管在考虑多重比较校正时，估计值很小且不显著。结论：在我们的队列研究中，我们没有发现妊娠早期邻苯二甲酸盐暴露与胎儿阴茎长度或宽度之间有临床意义的关联。影响对纽约市孕妇妊娠早期邻苯二甲酸酯代谢物进行了评估。在妊娠≥18周和<24周进行的临床评估超声检查中回顾性测量阴茎长度和宽度。在这个队列中，没有观察到妊娠早期产前邻苯二甲酸盐暴露与胎儿阴茎长度之间有临床意义的关联。本研究对产前邻苯二甲酸盐暴露对男性胎儿生殖器发育影响的研究有所贡献。结果强调，产前邻苯二甲酸盐暴露与胎儿阴茎长度和宽度之间可能没有明确的关联，可能需要进一步研究这一主题。
BackgroundPhthalates are endocrine-disrupting chemicals with anti-androgenic qualities and studies reported associations between prenatal phthalate exposure and infant genitalia. This study investigated whether increased prenatal phthalate exposure is associated with decreased fetal penile measures.MethodsData was from the New York University Children’s Health and Environment Study (2016–2019). Maternal urinary concentrations of 16 phthalate metabolites were quantified at <18 weeks gestation as a proxy for fetal exposure (n= 334 male pregnancies). We retrospectively measured penile length and width using ultrasounds conducted 18–24 weeks gestation (n= 173 fetuses). Associations of maternal urinary levels of phthalates with fetal penile length and width were determined using linear regression models.Results57.2% of women were Hispanic, 31.8% Non-Hispanic White, 6.4% Asian, 2.3% Non-Hispanic Black, and 2.3% multiple races. Mean maternal age was 32 years (standard deviation [SD] = 5.7). Mean penile length was 7.13 mm (SD = 1.47) and width was 6.16 mm (SD = 0.87). An inverse relationship was observed between maternal levels of mono-ethyl phthalate and fetal penile length, and mono-(7-carboxy-n-heptyl) phthalate and penile width, though estimates were small and not significant when considering correction for multiple comparisons.ConclusionsIn our cohort we found no clinically meaningful associations between early pregnancy phthalate exposure and fetal penile length or width.ImpactFirst-trimester phthalate metabolites were assessed in pregnant women in New York City.Penile length and width were retrospectively measured on clinically assessed ultrasounds conducted ≥18 weeks and <24 weeks of gestation.In this cohort, no clinically meaningful associations were observed between first-trimester prenatal phthalate exposure and fetal penile length.This study contributes to the limited but growing research on the impact of prenatal phthalate exposure on male fetal genital development.The results emphasize that there may not be a clear association between prenatal phthalate exposure and fetal penile length and width, and further research on this topic may be required.