Detection of anti‐idiotype reactive cells in the response to phosphorylcholine
Detection of anti‐idiotype reactive cells in the response to phosphorylcholine
复制标题
检测抗独特型反应细胞对磷酸胆碱的反应
DOI：
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发表时间：
1976
影响因子：
5.4
通讯作者：
H. Cosenza
中科院分区：
文献类型：
--
作者：
H. Cosenza
Upon immunization with phosphorylcholine (PC), BALB/c mice produce antibodies bearing mainly one idiotype which is identical to that of the TEPC 15 PC‐binding myeloma protein. By coating sheep red cells (SRC) with TEPC 15 it was possible to detect anti‐idiotypic plaques during the course of an immune response to PC. These plaques are detectable only after the anti‐PC response has reached a peak and begun to decline. They are specific, since addition of free TEPC 15 and not MOPC 315 prevented their detection. It is suggested that such anti‐idiotypic reactive cells might regulate the response to PC.
