Chagas' disease and AIDS.
Chagas' disease and AIDS.
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DOI：
10.1186/1475-9292-3-2
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发表时间：
2004-05-13
期刊：
影响因子：
--
通讯作者：
Tanowitz, Herbert B
中科院分区：
文献类型：
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作者：
Vaidian, Anil K;Weiss, Louis M;Tanowitz, Herbert B
由克氏锥虫引起的恰加斯病是艾滋病毒/艾滋病背景下的一种机会性感染。一些HIV感染者和慢性T。克氏病毒感染可能会重新激活，最常见的表现是脑膜脑炎。再活化心肌炎是第二个最常见的表现。这些表现可能很难与艾滋病毒/艾滋病患者的弓形虫病区分开来。艾滋病毒和克氏锥虫感染的重叠不仅发生在流行地区，而且也发生在北美和欧洲的非流行地区，在那里诊断可能更加困难。本文对本病的病理特点、诊断及细胞因子在发病机制中的作用进行了讨论。
Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is most commonly manifested by meningoencephalitis. A reactivation myocarditis is the second most common manifestation. These presentations may be difficult to distinguish from toxoplasmosis in individuals with HIV/AIDS. The overlap of HIV and Trypanosoma cruzi infection occurs not only in endemic areas but also in non-endemic areas of North America and Europe where the diagnosis may be even more difficult. The pathological features, diagnosis and the role of cytokines in the pathogenesis of the disease are discussed.