Polyunsaturated fatty acids production and transformation by Mortierella alpina and anaerobic bacteria
Polyunsaturated fatty acids production and transformation by Mortierella alpina and anaerobic bacteria
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DOI：
10.1002/ejlt.201200069
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发表时间：
2012-10-01
影响因子：
2.7
通讯作者：
Shimizu, Sakayu
中科院分区：
文献类型：
--
作者：
Ogawa, Jun;Sakuradani, Eiji;Shimizu, Sakayu
微生物作为多种多不饱和脂肪酸（PUFA）的生产者和作为催化剂将它们转化为除了普通PUFA之外的独特分子物种是有前途的。本文介绍了一株产油丝状真菌高山被孢霉1 S-4的化学诱变和分子育种以及利用厌氧细菌转化PUFA的方法。M. alpina 1 S-4及其突变体和转化体产生的油不仅含有常见的N-？6和n？3种PUFA，也有罕见的PUFA。在厌氧细菌中发现了独特的PUFA转化活性。它们将PUFA异构化为共轭脂肪酸，并以羟基脂肪酸为中间体进一步转化为部分饱和脂肪酸。这些独特的多不饱和脂肪酸的功能已经引起了人们的广泛关注，以改善我们的健康和开发新的化学材料。
Microorganisms are promising as producers of various polyunsaturated fatty acids (PUFAs) and as catalysts transforming them into unique molecular species beyond common PUFAs. This article describes PUFA production through chemical mutant- and molecular-breeding of an oleaginous filamentous fungus Mortierella alpina 1S-4 and PUFA transformation by anaerobic bacteria. M. alpina 1S-4 and its mutants and transformants produce oils containing not only common n?-?6 and n?-?3 PUFAs but also rare PUFAs. Unique PUFA-transforming activities were found in anaerobic bacteria. They isomerized PUFA to conjugated fatty acids and further transformed to partially saturated fatty acids with hydroxyl fatty acids as intermediates. The functions of these unique PUFAs have been attracting much attention for improving our health and for developing new chemical materials.