Exploiting Radiation Induction of Antigens in Cancer: Targeted Drug Delivery.
Exploiting Radiation Induction of Antigens in Cancer: Targeted Drug Delivery.
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DOI：
10.3390/ijms23063041
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发表时间：
2022-03-11
影响因子：
5.6
通讯作者：
Hallahan DE
中科院分区：
文献类型：
--
作者：
Kapoor V;Singh AK;Lewis CD;Deore S;Hallahan DE
用于治疗癌症的治疗性抗体对晚期疾病患者有效。例如，激活T淋巴细胞的抗体改善了许多癌症亚型的存活率。此外，抗体-药物缀合物有效地靶向对癌症特异性的细胞毒性剂。这篇综述讨论了辐射诱导抗原，这是压力调节蛋白，在癌症中过度表达。这些可诱导的细胞表面蛋白在细胞对遗传毒性应激的反应期间变得可接近抗体结合。铅抗原在所有组织学亚型和几乎所有晚期癌症中被诱导，但在正常组织中几乎没有表达。通过使用与这些应激调节蛋白特异性结合的治疗性抗体来利用诱导性抗原。与诱导型抗原GRP 78和TIP 1结合的抗体增强了放射治疗在临床前癌症模型中的功效。细胞毒性药物与抗体的偶联进一步改善癌症反应。本文综述了放射治疗在控制治疗性抗体和抗体-药物偶联物的癌症特异性结合方面的应用。
Therapeutic antibodies used to treat cancer are effective in patients with advanced-stage disease. For example, antibodies that activate T-lymphocytes improve survival in many cancer subtypes. In addition, antibody–drug conjugates effectively target cytotoxic agents that are specific to cancer. This review discusses radiation-inducible antigens, which are stress-regulated proteins that are over-expressed in cancer. These inducible cell surface proteins become accessible to antibody binding during the cellular response to genotoxic stress. The lead antigens are induced in all histologic subtypes and nearly all advanced-stage cancers, but show little to no expression in normal tissues. Inducible antigens are exploited by using therapeutic antibodies that bind specifically to these stress-regulated proteins. Antibodies that bind to the inducible antigens GRP78 and TIP1 enhance the efficacy of radiotherapy in preclinical cancer models. The conjugation of cytotoxic drugs to the antibodies further improves cancer response. This review focuses on the use of radiotherapy to control the cancer-specific binding of therapeutic antibodies and antibody–drug conjugates.
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影响因子：
11.2
作者：
Green DJ;Frayo SL;Lin Y;Hamlin DK;Fisher DR;Frost SH;Kenoyer AL;Hylarides MD;Gopal AK;Gooley TA;Orozco JJ;Till BG;O'Steen S;Orcutt KD;Wilbur DS;Wittrup KD;Press OW
通讯作者：
Press OW
影响因子：
15.9
作者：
Gul, Nuray;Babes, Liane;van Egmond, Marjolein
通讯作者：
van Egmond, Marjolein
影响因子：
50.3
作者：
Hallahan, D;Geng, L;Clanton, J
通讯作者：
Clanton, J
影响因子：
5.6
作者：
Gogesch P;Dudek S;van Zandbergen G;Waibler Z;Anzaghe M
通讯作者：
Anzaghe M
影响因子：
--
作者：
Dadey DY;Kapoor V;Khudanyan A;Urano F;Kim AH;Thotala D;Hallahan DE
通讯作者：
Hallahan DE